Compartments and Connections Within the Germinal Center.
Compartments and Connections Within the Germinal Center.
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DOI：
10.3389/fimmu.2021.659151
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发表时间：
2021
影响因子：
7.3
通讯作者：
Clark MR
中科院分区：
文献类型：
--
作者：
Kennedy DE;Clark MR
Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been appreciated since 1930, a wealth of recent progress provides new insights into the molecular and cellular dynamics governing humoral immunity. In this review, we highlight advances that demonstrate that fundamental GC B cell function, selection, proliferation and SHM occur within distinct cell states. The resulting new model provides new opportunities to understand the evolution of immunity in infectious, autoimmune and neoplastic diseases.
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