Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product.
Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product.
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DOI：
10.3390/molecules29010279
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发表时间：
2024-01-04
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影响因子：
--
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单萜类和高萜类是由陆生植物和单细胞生物产生的两大类异戊二烯类分子。全球癌症发病率的上升导致了对天然产品的新兴趣。这些单萜和meroterpenes代表了一种新的分子支架来源，可以作为药物化学平台，用于开发潜在的临床前线索。此外，这些天然产物中的一些是丰富的，或者它们的合成策略是可扩展的，如这里将指出的，促进它们的衍生化以扩大它们在药物发现中的范围。本综述收集了生物活性单萜和部分萜类天然产物的代表性更新（从2016年至2023年），并重点介绍了这些生物活性化合物的药理潜力的最新发现以及用于获得它们的新开发的合成策略。特别强调的是，将放在这些化合物的抗癌和抗氧化潜力，以提高知识，为进一步调查潜在的抗癌治疗的发展。来自地球仪的各种研究小组关于在临床前水平使用这些天然产品的实验证据越来越多，使它们成为值得关注的快速研究领域。
Monoterpenes and meroterpenes are two large classes of isoprene-based molecules produced by terrestrial plants and unicellular organisms as diverse secondary metabolites. The global rising incidence of cancer has led to a renewed interest in natural products. These monoterpenes and meroterpenes represent a novel source of molecular scaffolds that can serve as medicinal chemistry platforms for the development of potential preclinical leads. Furthermore, some of these natural products are either abundant, or their synthetic strategies are scalable as it will be indicated here, facilitating their derivatization to expand their scope in drug discovery. This review is a collection of representative updates (from 2016–2023) in biologically active monoterpene and meroterpenoid natural products and focuses on the recent findings of the pharmacological potential of these bioactive compounds as well as the newly developed synthetic strategies employed to access them. Particular emphasis will be placed on the anticancer and antioxidant potential of these compounds in order to raise knowledge for further investigations into the development of potential anti-cancer therapeutics. The mounting experimental evidence from various research groups across the globe regarding the use of these natural products at pre-clinical levels, renders them a fast-track research area worth of attention.
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影响因子：
4.1
作者：
Assali, Mohyeddin;Jaradat, Nidal;Maqboul, Lana
通讯作者：
Maqboul, Lana
DOI：
10.3390/molecules28052366
发表时间：
2023-03-04
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Calva J;Cartuche L;Castillo LN;Morocho V
通讯作者：
Morocho V
影响因子：
8.4
作者：
Chong, Chuanke;Chang, Le;Grimm, Isabelle;Zhang, Qunlong;Kuang, Yang;Wang, Bingjian;Kang, Jingyi;Liu, Wenhui;Baars, Julian;Guo, Yuanqiang;Schmalz, Hans-Guenther;Lu, Zhaoyong
通讯作者：
Lu, Zhaoyong
影响因子：
1.8
作者：
Cragg, GM;Newman, DJ
通讯作者：
Newman, DJ
影响因子：
5.5
作者：
Abu-Serie, Marwa M.;Andrade, Fernanda;Schwartz, Simo, Jr.
通讯作者：
Schwartz, Simo, Jr.