Endogenous digitalis-like factors: an overview of the history.
Endogenous digitalis-like factors: an overview of the history.
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内源性数字般的因素：历史的概述。
DOI：
10.3389/fendo.2015.00049
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发表时间：
2015
影响因子：
5.2
通讯作者：
Buckalew VM
中科院分区：
文献类型：
--
作者：
Buckalew VM
钠泵是一种普遍存在的细胞表面酶，是一种Na，K-ATPase，它维持细胞和细胞外液(ECF)之间的离子梯度。这种酶的胞外区含有一个高度保守的结合部位，是一种植物来源的化合物家族的受体，洋地黄苷。这些化合物抑制这种酶，用于治疗充血性心力衰竭和某些心律失常。这种酶及其洋地黄受体的高度保守性导致了早期的暗示，即可能存在内源性调节因子。最近对这一假说的检验出现在两个不同的领域：由利钠激素(NH)调节ECF容量，以及由循环中的血管Na，K-ATPase抑制物调节外周血管阻力。这两个区域合并了一种假设，即NH和血管Na，K-ATPase抑制剂实际上是同一实体，并在某些类型的高血压的病理生理中起到了致病作用。多种内源性洋地黄样因子(EDLF)存在的可能性来自于对循环酶抑制活性的研究。本文回顾了这一领域的发展历程，简要讨论了掺铒光纤的结构现状，并提出了今后的发展方向。
The sodium pump is a ubiquitous cell surface enzyme, a Na, K ATPase, which maintains ion gradients between cells and the extracellular fluid (ECF). The extracellular domain of this enzyme contains a highly conserved binding site, a receptor for a plant derived family of compounds, the digitalis glycosides. These compounds inhibit the enzyme and are used in the treatment of congestive heart failure and certain cardiac arrhythmias. The highly conserved nature of this enzyme and its digitalis receptor led to early suggestions that endogenous regulators might exist. Recent examination of this hypothesis emerged from research in two separate areas: the regulation of ECF volume by a natriuretic hormone (NH), and the regulation of peripheral vascular resistance by a circulating inhibitor of vascular Na, K ATPase. These two areas merged with the hypothesis that NH and the vascular Na, K ATPase inhibitor were in fact the same entity, and that it played a causative role in the pathophysiology of certain types of hypertension. The possibility that multiple endogenous digitalis-like factors (EDLFs) exist emerged from efforts to characterize the circulating enzyme inhibitory activity. In this review, the development of this field from its beginnings is traced, the current status of the structure of EDLFs is briefly discussed, and areas for future development are suggested.
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影响因子：
21.1
作者：
Bagrov AY;Shapiro JI;Fedorova OV
通讯作者：
Fedorova OV
影响因子：
15.9
作者：
BUCKALEW, VM;MARTINEZ, FJ;GREEN, WE
通讯作者：
GREEN, WE
影响因子：
5
作者：
BAGROV, AY;ROUKOYATKINA, NI;FEDOROVA, OV
通讯作者：
FEDOROVA, OV
影响因子：
19.6
作者：
BUCKALEW, VM;NELSON, DB
通讯作者：
NELSON, DB
影响因子：
--
作者：
Correa, Alicia H.;Choi, Marcelo R.;Fernandez, Belisario E.
通讯作者：
Fernandez, Belisario E.