Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study.
Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study.
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从事非自杀自伤的儿童的神经奖励反应能力：ERP研究。
DOI：
10.1111/jcpp.12919
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Gibb BE
中科院分区：
文献类型：
--
作者：
Tsypes A;Owens M;Hajcak G;Gibb BE
更好地了解儿童非自杀性自伤（NSSI）的相关性对于识别和预防未来的自杀风险非常重要。然而，尽管奖励反应异常可能构成了一个潜在的风险转诊断机制为NSSI，没有研究已经检查了初始响应奖励的儿童与历史的NSSI。本研究的目的是解决文献中的这一重要空白。为了客观地评估奖励的初始反应，我们利用了反馈负性（FN）事件相关电位，这是奖励反应性的一个公认的心理生理学标记。参与者是57名7至11岁的儿童（19名有NSSI病史，38名人口统计学匹配的对照）。诊断性访谈用于评估当前和过去的DSM-IV情绪和焦虑诊断以及NSSI历史。孩子们还完成了一项猜测任务，在此期间，连续记录脑电图。有NSSI病史的儿童表现出明显更负的ΔFN（即，FN的损失减去FN的收益）比儿童没有NSSI。这些发现似乎至少部分独立于儿童的精神病理学史和当前症状，表明其特异性NSSI。这些结果提供了初步的证据，提高神经初始奖励反应的损失与奖励的儿童与历史的NSSI。在重复和纵向研究之前，ΔFN可能代表了自我伤害风险的心理生理学标志。
A better understanding of the correlates of nonsuicidal self-injury (NSSI) in children is important for the identification and prevention of future suicide risk. However, although abnormalities in reward responsiveness might constitute one potential transdiagnostic mechanism of risk for NSSI, no studies have examined initial response to reward in children with a history of NSSI. The goal of the present study was to address this important gap in the literature. To objectively assess initial response to reward, we utilized the feedback negativity (FN) event-related potential, a well-established psychophysiological marker of reward responsiveness. Participants were 57 children (19 with a history of NSSI and 38 demographically-matched controls) between the ages of 7 and 11. Diagnostic interviews were used to assess for current and past DSM-IV mood and anxiety diagnoses and NSSI history. Children also completed a guessing task, during which continuous electroencephalography was recorded. Children with a history of NSSI exhibited significantly more negative ΔFN (i.e., FN to losses minus FN to gains) than children without NSSI. These findings appeared to be at least partially independent of children’s history of psychopathology and current symptoms, suggesting their specificity to NSSI. These results provide initial evidence for heightened neural initial reward responsiveness to losses versus rewards in children with a history of NSSI. Pending replications and longitudinal studies, the ΔFN might represent a psychophysiological marker of risk for self-harm.
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影响因子：
8
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Abela, John R. Z.
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