Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine.
Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine.
复制标题
膳食铁摄入量和血清铁蛋白与严重头痛或偏头痛之间的关联
DOI：
10.3389/fnut.2021.685564
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发表时间：
2021
影响因子：
5
通讯作者：
Zhao YS
中科院分区：
文献类型：
--
作者：
Meng SH;Zhou HB;Li X;Wang MX;Kang LX;Fu JM;Li X;Li XT;Zhao YS
背景：膳食铁摄入量和血清铁蛋白与严重头痛或偏头痛的关系尚不清楚。因此，我们调查了美国成年人饮食铁摄入量和血清铁蛋白与严重头痛或偏头痛之间的关系。研究方法：这项横断面研究包括1999年至2004年美国国家健康和营养调查（NHANES）的7，880名成年人（≥20岁）。我们进行了多变量逻辑回归和限制性三次样条（RCS）回归，以评估膳食铁和血清铁蛋白与严重头痛或偏头痛的关系。结果：大多数年龄在20-50岁的妇女摄入的膳食铁低于其推荐的膳食供给量。在20-50岁的女性中，膳食铁摄入量与严重头痛或偏头痛呈负相关。对于50岁以上的女性，血清铁蛋白与严重头痛或偏头痛呈负相关。对于男性，饮食铁和血清铁蛋白与严重头痛或偏头痛之间没有显著关系。结论：膳食铁摄入量对不同年龄女性的偏头痛有不同的影响，这种不同的影响可能是由于年龄相关的月经变化。20-50岁的女性应该对RDA有更高的认识，并在必要时增加膳食铁的摄入量，这可能在预防严重头痛或偏头痛方面发挥重要作用。50岁及以上女性血清铁蛋白水平较高可能对偏头痛有保护作用。
Background: Dietary iron intake and serum ferritin in relation to severe headache or migraine remain largely unknown. Therefore, we investigated the associations between dietary iron intake and serum ferritin with severe headache or migraine among American adults. Methods: This cross-sectional study included 7,880 adults (≥20 years) from the National Health and Nutrition Examination Surveys (NHANES) of America from 1999 to 2004. We performed multivariable logistic regression and restricted cubic spline (RCS) regression to assess the association of dietary iron and serum ferritin with severe headache or migraine. Results: Most women aged 20–50 years consumed less dietary iron than their recommended dietary allowances. Dietary iron intake was inversely associated with severe headache or migraine in women aged 20–50 years. For women over 50 years, serum ferritin was negatively associated with severe headache or migraine. For men, there was no significant relationship between dietary iron and serum ferritin, and severe headache or migraine. Conclusions: Dietary iron intake has different effects on migraine in women of different ages, and this different effect may be due to age-related menstrual changes. Women aged 20–50 years should have a higher awareness of RDA and increase their dietary iron intake if needed, which may play an important role in preventing severe headache or migraine. Higher serum ferritin levels in women aged 50 and above may have a protective effect against migraine.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
4.7
作者：
Dučić T;Barski E;Salome M;Koch JC;Bähr M;Lingor P
通讯作者：
Lingor P
影响因子：
9.9
作者：
Dominguez, Clara;Lopez, Ana;Leira, Rogelio
通讯作者：
Leira, Rogelio
DOI：
10.3945/ajcn.116.147389
发表时间：
2017-06
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Fairweather-Tait SJ;Jennings A;Harvey LJ;Berry R;Walton J;Dainty JR
通讯作者：
Dainty JR
影响因子：
4.2
作者：
Lozoff, Betsy
通讯作者：
Lozoff, Betsy