The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection.
The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection.
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DOI：
10.1111/irv.12470
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发表时间：
2017-09
影响因子：
4.4
通讯作者：
Fischer WA 2nd
中科院分区：
文献类型：
--
作者：
Sellers SA;Hagan RS;Hayden FG;Fischer WA 2nd
严重流感感染是全球发病率和死亡率的主要原因。虽然流感主要被认为是一种病毒感染，导致的病理学仅限于呼吸系统，但临床报告表明，流感感染经常与涉及呼吸道外器官系统的许多临床综合征相关。使用器官特异性检索词，对与流感感染肺外并发症相关的文章进行了全面的MEDLINE文献综述，获得了218篇文章，包括病例报告、流行病学调查和尸检研究，对这些文章进行了综述，以确定其他器官的临床累及。最常描述的临床实体是病毒性心肌炎和病毒性脑炎。识别这些肺外并发症对于确定流感感染的真正负担和启动器官特异性支持性治疗至关重要。
Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.
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