Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018.
Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Camel Populations, Southern Jordan, 2014-2018.
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2014-2018年约旦南部骆驼感染中东呼吸综合征冠状病毒的危险因素分析
DOI：
10.3201/eid2709.203508
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发表时间：
2021-09
影响因子：
11.8
通讯作者：
Guitian J
中科院分区：
文献类型：
--
作者：
Holloway P;Gibson M;van Doremalen N;Nash S;Holloway T;Letko M;Cardwell JM;Al Omari B;Al-Majali A;Abu-Basha E;Mangtani P;Munster VJ;Guitian J
2013年在约旦的骆驼中首次检测到中东呼吸综合征冠状病毒（MERS-CoV）后，我们在2014-2015年和2017-2018年进行了两次连续调查，调查约旦南部骆驼种群中MERS-CoV感染的风险因素。控制混杂因素的多变量分析表明，出于繁殖目的而借用骆驼，特别是雄性骆驼，与接收牛群中MERS CoV血清阳性率增加相关，表明牛群之间存在潜在的病毒传播途径。年龄的增加、畜群规模的扩大和畜群内水槽的使用也与血清阳性率的增加有关。发现封闭式畜群管理做法具有保护作用。约旦骆驼种群未来的疫苗接种策略可能会优先考虑繁殖雄性，这可能会在牛群之间共享。此外，应考虑有可能减少畜群之间传播的有针对性的管理干预措施;自愿封闭畜群计划为实现无病畜群提供了可能的途径。
After the first detection of Middle East respiratory syndrome coronavirus (MERS-CoV) in camels in Jordan in 2013, we conducted 2 consecutive surveys in 2014–2015 and 2017–2018 investigating risk factors for MERS-CoV infection among camel populations in southern Jordan. Multivariate analysis to control for confounding demonstrated that borrowing of camels, particularly males, for breeding purposes was associated with increased MERS-CoV seroprevalence among receiving herds, suggesting a potential route of viral transmission between herds. Increasing age, herd size, and use of water troughs within herds were also associated with increased seroprevalence. Closed herd management practices were found to be protective. Future vaccination strategies among camel populations in Jordan could potentially prioritize breeding males, which are likely to be shared between herds. In addition, targeted management interventions with the potential to reduce transmission between herds should be considered; voluntary closed herd schemes offer a possible route to achieving disease-free herds.
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