In vivo fate tracing studies of mammalian taste cell progenitors.
In vivo fate tracing studies of mammalian taste cell progenitors.
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DOI：
10.1111/j.1749-6632.2009.04371.x
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发表时间：
2009-07
影响因子：
5.2
通讯作者：
Barlow LA
中科院分区：
文献类型：
--
作者：
Thirumangalathu S;Barlow LA
在哺乳动物中，同质的舌上皮在发育过程中形成特化的基板细胞，其经历一系列形态发生变化以形成乳头。味蕾在出生时出现在乳头状上皮中，因此乳头状上皮用于容纳成年人的味蕾。然而，到目前为止，一个假定的胚胎味觉祖细胞群体和功能性成人味蕾之间的精确谱系关系的证据是难以捉摸的，主要是间接的。此外，哺乳动物的味觉乳头让人联想到上皮附属物，这表明乳头的间充质组织可能参与这些舌结构的形成。这些在哺乳动物味觉发育领域的主要问题仍然没有答案，因为缺乏标记胚胎细胞群体并在成年人中保持不可磨灭的标记的命运作图研究。利用遗传命运映射方法来标记舌上皮和间充质中的细胞群，并在发育过程中跟踪它们的命运，将是评估这些组织中的每一个在味蕾形成中的贡献的理想方式。使用组织特异性cre菌株与报告基因杂交的命运定位研究将揭示这些特化感觉细胞形成的独特特征，并为我们在发育过程中的味觉器官特异性实验操作提供体内模型系统。
In mammals, the homogeneous lingual epithelium in the process of development, forms specialized placodal cells that undergo a series of morphogenetic changes to form a papilla. Taste buds appear in the papillary epithelium around birth and thus papillae serve to house the taste buds in the adult. However, evidence for a precise lineage relationship between a putative embryonic taste progenitor population and functional adult taste buds has so far been elusive and is primarily indirect. Also, mammalian taste papillae are reminiscent of epithelial appendages suggesting that the mesenchymal tissue of the papillae could be involved in the formation of these lingual structures. These major questions in the field of mammalian taste development have remained unanswered due to lack of fate mapping studies that would label embryonic cell populations and remain indelibly marked in the adult. Taking advantage of a genetic fate mapping approach to label cell populations both in the lingual epithelium and mesenchyme and following their fate during development would be an ideal way to assess each of these tissues contribution in taste bud formation. Fate-mapping studies using tissue specific cre strains crossed with reporter alleles would uncover unique features in the formation of these specialized sensory cells and also provide us with an in vivo model system for taste organ specific experimental manipulations during development.
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影响因子：
2.7
作者：
Mistretta, CM;Liu, HX;MacCallum, DK
通讯作者：
MacCallum, DK
影响因子：
2.7
作者：
Liu, HX;MacCallum, DK;Mistretta, CM
通讯作者：
Mistretta, CM
影响因子：
2.5
作者：
Mbiene, JP;Roberts, JD
通讯作者：
Roberts, JD
DOI：
10.1073/pnas.0607399104
发表时间：
2007-02-13
影响因子：
11.1
作者：
Iwatsuki, Ken;Liu, Hong-Xiang;Margolskee, Robert F.
通讯作者：
Margolskee, Robert F.
影响因子：
2.5
作者：
Nakayama, Ayumi;Miura, Hirohito;Harada, Shuitsu
通讯作者：
Harada, Shuitsu