PCOS Forum: research in polycystic ovary syndrome today and tomorrow.
PCOS Forum: research in polycystic ovary syndrome today and tomorrow.
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DOI：
10.1111/j.1365-2265.2010.03956.x
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发表时间：
2011-04
影响因子：
3.2
通讯作者：
Legro RS
中科院分区：
文献类型：
--
作者：
Pasquali R;Stener-Victorin E;Yildiz BO;Duleba AJ;Hoeger K;Mason H;Homburg R;Hickey T;Franks S;Tapanainen JS;Balen A;Abbott DH;Diamanti-Kandarakis E;Legro RS
总结多囊卵巢综合征（PCOS）的研究前景，促进该领域的进一步研究。进一步研究活动的潜在领域包括分析增加多囊症风险的易感条件，特别是遗传背景和环境因素，如内分泌干扰物和生活方式。雄激素过量可能导致胰岛素抵抗的概念需要从发育的角度重新审视，因为动物研究已经支持了早期暴露于适度雄激素过量与胰岛素抵抗有关的假设。确定多囊卵巢综合征中甾体生成的改变应量化卵巢、肾上腺和腺体外的贡献，并通过某种通用标准明确定义血液参考水平。卵泡发育的卵巢内调控和卵泡阻滞的机制有待进一步阐明。最后，多囊卵巢综合征状态预计会对女性产生长期影响，特别是2型糖尿病、心血管疾病和激素依赖性癌症的发展。通过基因组学和蛋白质组学方法识别易感个体将有助于个体化治疗和预防。我们审查的一个潜在限制是，我们选择性地关注了我们认为最具争议的领域。
To summarize promising areas of investigation into polycystic ovary syndrome (PCOS) and to stimulate further research in this area. Potential areas of further research activity include the analysis of predisposing conditions that increase the risk of PCOS, particularly genetic background and environmental factors, such as endocrine disruptors and lifestyle. The concept that androgen excess may contribute to insulin resistance needs to be re-examined from a developmental perspective, since animal studies have supported the hypothesis that early exposure to modest androgen excess is associated with insulin resistance. Defining alterations of steroidogenesis in PCOS should quantify ovarian, adrenal and extraglandular contribution, as well as clearly define blood reference levels by some universal standard. Intraovarian regulation of follicle development and mechanisms of follicle arrest should be further elucidated. Finally, PCOS status is expected to have long-term consequences in women, specifically the development of type 2 diabetes, cardiovascular diseases and hormone dependent cancers. Identifying susceptible individuals through genomic and proteomic approaches would help to individualize therapy and prevention. A potential limitation of our review is that we focused selectively on areas we viewed as the most controversial.
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影响因子：
4.7
作者：
Diamanti-Kandarakis, Evanthia;Piperi, Christina;Papavassiliou, Athanasios G.
通讯作者：
Papavassiliou, Athanasios G.
影响因子：
3.2
作者：
Draper, Nicole;Powell, Brenda L.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
3.2
作者：
Barth, JH;Jenkins, M;Belchetz, PE
通讯作者：
Belchetz, PE
影响因子：
5.8
作者：
Eisner, JR;Dumesic, DA;Abbott, DH
通讯作者：
Abbott, DH