Brain activation patterns underlying upper limb bilateral motor coordination in unilateral cerebral palsy: an fNIRS study.
Brain activation patterns underlying upper limb bilateral motor coordination in unilateral cerebral palsy: an fNIRS study.
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DOI：
10.1111/dmcn.14458
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发表时间：
2020-05
影响因子：
3.8
通讯作者：
Damiano DL
中科院分区：
文献类型：
--
作者：
de Campos AC;Sukal-Moulton T;Huppert T;Alter K;Damiano DL
探讨单侧脑瘫 (CP) 双手任务期间的皮质激活和功能相关性。这项横断面研究包括手动能力分类系统 II 至 III 级的 8 名单侧 CP 参与者（6 名女性，2 名男性；平均年龄 [SD] 20y 10mo [5y 10mo]、13y 8mo–31y 6mo）和 9 名具有典型发育的年龄匹配参与者（7 名女性，2 名男性；平均年龄 [SD] 17y 8mo [5y 7mo]、9y） 4 个月–24 年 2 个月）。他们以 1Hz 的频率执行双手对称挤压 (BSS) 和双手不对称挤压 (BAS) 任务，并以 0.67Hz 的频率执行惯用手的倾倒任务 (DPour) 和非惯用手的倾倒任务 (NDPour)，同时将定制的功能性近红外光谱 (fNIRS) 光极阵列放置在他们的感觉运动区域上。使用混合效应来对比组、任务和半球（报告了校正的 p 值 [q]）。方差分析和 t 检验比较了各组和任务的绩效指标。与典型发育的参与者相比，单侧 CP 的参与者在 BAS 期间（非病变：q<0.001；病变：q<0.001）以及 BSS（q<0.001）、DPour（q=0.02）和 NDPour（q=0.02）期间病变半球表现出更大的激活。单侧 CP 中受损的半球比未受损的半球表现出更多的活动（BSS：q=0.01；BAS：q=0.009；NDPour：q=0.04）。在 BAS 期间，较高的皮质活动与更多的同步手臂激活相关（r=0.79；p=0.02）；偏向非病变半球的活动与更好的儿科残疾评估清单计算机适应性测试分数相关（r = 0.81；p = 0.03）。结果表明单侧 CP 的感觉运动皮层活动异常增加，其影响有待研究。
To explore cortical activation during bimanual tasks and functional correlates in unilateral cerebral palsy (CP). This cross-sectional study included eight participants with unilateral CP (six females, two males; mean age [SD] 20y 10mo [5y 10mo], 13y 8mo–31y 6mo) in Manual Ability Classification System levels II to III and nine age-matched participants with typical development (seven females, two males; mean age [SD] 17y 8mo [5y 7mo], 9y 4mo–24y 2mo). They performed bimanual symmetric squeezing (BSS) and bimanual asymmetric squeezing (BAS) tasks at 1Hz, and a pouring task with dominant hand (DPour) and a pouring task with non-dominant hand (NDPour) at 0.67Hz, all while a custom array of functional near-infrared spectroscopy (fNIRS) optodes were placed over their sensorimotor area. Mixed-effects were used to contrast groups, tasks, and hemispheres (corrected p-values [q] reported). Analysis of variance and t-tests compared performance measures across groups and tasks. Participants with unilateral CP showed greater activation in both hemispheres during BAS (non-lesioned: q<0.001; lesioned: q<0.001), and in the lesioned hemisphere during BSS (q<0.001), DPour (q=0.02), and NDPour (q=0.02) than those with typical development. The lesioned hemisphere in unilateral CP showed more activity than the non-lesioned one (BSS: q=0.01; BAS: q=0.009; NDPour: q=0.04). During BAS, higher cortical activity correlated with more synchronous arm activation (r=0.79; p=0.02); activity lateralized towards the non-lesioned hemisphere correlated with better Pediatric Evaluation of Disability Inventory computer adaptive test scores (r=0.81; p=0.03). Results suggest abnormally increased sensorimotor cortical activity in unilateral CP, with implications to be investigated.
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DOI：
10.1111/jon.12432
发表时间：
2017-09
期刊：
Journal of neuroimaging : official journal of the American Society of Neuroimaging
影响因子：
--
作者：
Chen M;Blumen HM;Izzetoglu M;Holtzer R
通讯作者：
Holtzer R
影响因子：
2.3
作者：
Santosa, Hendrik;Zhai, Xuetong;Huppert, Theodore
通讯作者：
Huppert, Theodore
影响因子：
3.8
作者：
Tian F;Delgado MR;Dhamne SC;Khan B;Alexandrakis G;Romero MI;Smith L;Reid D;Clegg NJ;Liu H
通讯作者：
Liu H
影响因子：
1.8
作者：
Swinnen, SP;Carson, RG
通讯作者：
Carson, RG
影响因子：
1.2
作者：
Sukal-Moulton, Theresa;de Campos, Ana Carolina;Damiano, Diane L.
通讯作者：
Damiano, Diane L.