Extracellular matrix as an inductive scaffold for functional tissue reconstruction.
Extracellular matrix as an inductive scaffold for functional tissue reconstruction.
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DOI：
10.1016/j.trsl.2013.11.003
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Badylak SF
中科院分区：
文献类型：
--
作者：
Brown BN;Badylak SF
细胞外基质（ECM）是一种由结构和功能蛋白组成的网络，具有独特的组织特异性结构。ECM既为每个组织和器官提供机械框架，又是细胞信号传导的底物。ECM是高度动态的，细胞既从ECM接收信号，又对其内容和组织做出贡献。这种“动态互惠”的过程是组织发育和体内平衡的关键。基于这些重要功能，ECM基材料已被用于各种组织工程和再生医学方法的组织重建。它已被证明，ECM为基础的材料，适当准备时，可以作为诱导模板建设性重塑。具体地，这样的材料充当用于诱导从头功能性的、位点适当的组织形成的模板。在此，ECM的不同结构和功能的作用进行了审查，以提供一个合理的ECM支架在再生医学中的使用。ECM支架在再生中的翻译例子，ECM支架引起建设性重塑的潜在机制进行了讨论。更好地理解ECM支架材料定义损伤部位微环境的能力将导致与其使用相关的临床结果的改善。
The extracellular matrix (ECM) is a meshwork of both structural and functional proteins assembled in unique tissue-specific architectures. The ECM both provides the mechanical framework for each tissue and organ and is a substrate for cell signaling. The ECM is highly dynamic, and cells both receive signals from the ECM and contribute to its content and organization. This process of “dynamic reciprocity” is key to tissue development and for homeostasis. Based upon these important functions, ECM-based materials have been used in a wide variety of tissue engineering and regenerative medicine approaches to tissue reconstruction. It has been demonstrated that ECM-based materials, when appropriately prepared, can act as inductive templates for constructive remodeling. Specifically, such materials act as templates for the induction of de novo functional, site-appropriate, tissue formation. Herein, the diverse structural and functional roles of the ECM are reviewed to provide a rationale for the use of ECM scaffolds in regenerative medicine. Translational examples of ECM scaffolds in regenerative are provided, and the potential mechanisms by which ECM scaffolds elicit constructive remodeling are discussed. A better understanding of the ability of ECM scaffold materials to define the microenvironment of the injury site will lead to improved clinical outcomes associated with their use.
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影响因子：
4.1
作者：
Agrawal, Vineet;Tottey, Stephen;Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.
DOI：
10.1073/pnas.0905851106
发表时间：
2010-02-23
影响因子：
11.1
作者：
Agrawal, Vineet;Johnson, Scott A.;Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.
DOI：
10.1097/00002480-198804000-00005
发表时间：
1988-04-01
期刊：
ASAIO transactions
影响因子：
--
作者：
Anderson, J M
通讯作者：
Anderson, J M
影响因子：
2.4
作者：
Badylak, S;Meurling, S;Simmons-Byrd, A
通讯作者：
Simmons-Byrd, A
影响因子：
4.1
作者：
Agrawal, Vineet;Siu, Bernard F.;Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.