The Effect of HIV and Antiretroviral Therapy on Drug-Resistant Tuberculosis Treatment Outcomes in Eastern Cape, South Africa: A Cohort Study.
The Effect of HIV and Antiretroviral Therapy on Drug-Resistant Tuberculosis Treatment Outcomes in Eastern Cape, South Africa: A Cohort Study.
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DOI：
10.3390/v15112242
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发表时间：
2023-11-10
期刊：
影响因子：
--
通讯作者：
Ramangeola L
中科院分区：
文献类型：
--
作者：
van de Water B;Abuelezam N;Hotchkiss J;Botha M;Ramangeola L
南非有艾滋病毒和耐药结核病（DR-TB）的双重高负担。我们试图了解艾滋病毒和抗逆转录病毒治疗状态与结核病治疗结果的关系。这是对2017年至2020年期间在南非东开普省两家耐药结核病医院开始治疗的246名患者的回顾性图表审查。考虑了三个级别的分类结局：不利、转出和成功。描述性统计和逻辑回归被用来比较个人没有艾滋病毒，艾滋病毒和抗逆转录病毒治疗（ART），艾滋病毒，但不对ART。64%的患者合并感染艾滋病毒，与87%的这些人在治疗开始时对ART。大多数（59%）患者的治疗结果成功。21%的病人被转移出去，另外21%的病人没有成功的结果。与接受抗逆转录病毒治疗的艾滋病毒感染者相比，未感染艾滋病毒的个体的成功几率是接受抗逆转录病毒治疗的艾滋病毒感染者的3.5倍以上，与未接受抗逆转录病毒治疗的艾滋病毒感染者相比，成功结局的几率是接受抗逆转录病毒治疗的艾滋病毒感染者的10倍以上（OR 3.64，95% CI 1.11，11.95; OR 10.24，95% CI 2.79，37.61）。艾滋病毒合并感染，特别是在未经治疗的情况下，与没有艾滋病毒合并感染的个体相比，治疗成功的几率显着降低。
South Africa has a dual high burden of HIV and drug-resistant TB (DR-TB). We sought to understand the association of HIV and antiretroviral therapy status with TB treatment outcomes. This was a retrospective chart review of 246 patients who began treatment at two DR-TB hospitals in Eastern Cape, South Africa between 2017 and 2020. A categorical outcome with three levels was considered: unfavorable, transferred out, and successful. Descriptive statistics and logistic regression were used to compare the individuals without HIV, with HIV and on antiretroviral therapy (ART), and with HIV but not on ART. Sixty-four percent of patients were co-infected with HIV, with eighty-seven percent of these individuals on ART at treatment initiation. The majority (59%) of patients had a successful treatment outcome. Twenty-one percent of patients transferred out, and an additional twenty-one percent did not have a successful outcome. Individuals without HIV had more than three and a half times the odds of success compared to individuals with HIV on ART and more than ten times the odds of a successful outcome compared to individuals with HIV not on ART (OR 3.64, 95% CI 1.11, 11.95; OR 10.24, 95% CI 2.79, 37.61). HIV co-infection, especially when untreated, significantly decreased the odds of treatment success compared to individuals without HIV co-infection.
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影响因子：
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作者：
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