Head and neck cancer stem cells: the side population.
Head and neck cancer stem cells: the side population.
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DOI：
10.1002/lary.21032
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发表时间：
2011-03
期刊：
影响因子：
2.6
通讯作者：
Prince, Mark E.
中科院分区：
文献类型：
--
作者：
Tabor, Mark H.;Clay, Matthew R.;Owen, John H.;Bradford, Carol R.;Carey, Thomas E.;Wolf, Gregory T.;Prince, Mark E.
癌症干细胞(CSC)假说的结论是，肿瘤细胞亚群可以自我更新，导致肿瘤生长、治疗失败和复发。一些肿瘤研究已经确定了能够外流Hoechst 33342染料的细胞；侧群(SP)。SP细胞和CSCs有许多共同的特征，提示从恶性肿瘤中分离出的SP含有CSCs。从头颈部癌细胞系中分离出SP，并对其CSC样特性进行分析。SP证明了仅用一个细胞就能同时复制SP和非侧群(NSP)细胞的能力。SP的活性β-连环蛋白表达较低，对5-氟尿嘧啶的耐受性较强，BMI-1和ABCG2的表达较高。在2例原发人类肿瘤中发现了SP。头颈部癌细胞系中的SP可作为CSCs的体外模型，为开发新的治疗策略提供了有价值的模型。
The cancer stem cell (CSC) hypothesis concludes that a subpopulation of tumor cells can self-renew, causing tumor growth, treatment failure, and recurrence. Several tumor studies have identified cells able to efflux Hoechst 33342 dye; the side population (SP). SP cells and CSCs share many characteristics, suggesting the SP isolated from malignant tumors contains CSCs. The SP was isolated from a head and neck cancer cell line and analyzed for CSC-like characteristics. The SP demonstrated the ability to reproduce both SP and non-side population (NSP) cells from as few as one cell. The SP had lower expression of active β-catenin and more resistance to 5-Fluorouracil; the SP also demonstrated greater expression of BMI-1 (4.3-fold) and ABCG2 (1.4-fold). SPs were identified in 2 primary human tumors. The SP in head and neck cancer cell lines may serve as a valuable in-vitro model for CSCs leading to the development of novel treatment strategies.
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影响因子：
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作者：
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DOI：
10.1016/s0006-291x(02)00275-9
发表时间：
2002-05-03
影响因子：
3.1
作者：
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通讯作者：
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