Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation.
Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation.
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DOI：
10.1016/j.neuropsychologia.2010.04.015
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发表时间：
2010-07
期刊：
影响因子：
2.6
通讯作者：
Lehmann H
中科院分区：
文献类型：
--
作者：
Sutherland RJ;Sparks FT;Lehmann H
海马损伤后的逆行性遗忘的特性已经用人类内侧颞叶遗忘的大鼠模型成功地解释了。我们回顾了这项实验工作的结果，重点放在几个领域的共识，在这个不断增长的文献。我们评估了理论上重要的假设，海马逆行性遗忘症通常表现出时间梯度，影响最近，但保留远程记忆。令人惊讶的是，证据并没有提供太多的支持的想法，有一个漫长的过程，系统巩固后的学习插曲。相反，最近和遥远的记忆往往同样受到影响。海马体的损伤程度是这项工作的一个重要因素，因为备用的海马体组织可能至少可以支持部分记忆提取。对于广泛的海马损伤，梯度是平坦的，或者在具有味道/气味检索线索的记忆任务的情况下，逆行性遗忘覆盖约1 - 3天的时间。有一致的证据表明，在学习的时候，海马干扰或掩盖其他系统的记忆获取。这有助于在大鼠中相对于顺行性遗忘的逆行性遗忘的广度和严重性。事实上，多个分布式学习片段可以克服这种阴影，这与并行双存储理论或分布式恢复理论是一致的，在这种理论中，每个学习片段都会触发一段短时间的记忆重放，从而提供短暂的依赖于记忆的系统巩固。
The properties of retrograde amnesia after damage to the hippocampus have been explicated with some success using a rat model of human medial temporal lobe amnesia. We review the results of this experimental work with rats focusing on several areas of consensus in this growing literature. We evaluate the theoretically significant hypothesis that hippocampal retrograde amnesia normally exhibits a temporal gradient, affecting recent, but sparing remote memories. Surprisingly, the evidence does not provide much support for the idea that there is a lengthy process of systems consolidation following a learning episode. Instead, recent and remote memories tend to be equally affected. The extent of damage to the hippocampus is a significant factor in this work since it is likely that spared hippocampal tissue can support at least partial memory retrieval. With extensive hippocampal damage gradients are flat or, in the case of memory tasks with flavour/odour retrieval cues, the retrograde amnesia covers a period of about 1 – 3 days. There is consistent evidence that at the time of learning the hippocampus interferes with or overshadows memory acquisition by other systems. This contributes to the breadth and severity of retrograde amnesia relative to anterograde amnesia in the rat. The fact that multiple, distributed learning episodes can overcome this overshadowing is consistent with a parallel dual-store theory or a Distributed Reinstatement Theory in which each learning episode triggers a short period of memory replay that provides a brief hippocampal-dependent systems consolidation.
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影响因子：
56.9
作者：
AVIS, HH;CARLTON, PL
通讯作者：
CARLTON, PL
影响因子：
3.5
作者：
Gaskin, S;Tremblay, A;Mumby, DG
通讯作者：
Mumby, DG
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
影响因子：
2
作者：
Epp, Jonathan;Keith, Julian R.;Sutherland, Robert J.
通讯作者：
Sutherland, Robert J.
DOI：
10.1037/0097-7403.19.2.121
发表时间：
1993-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
FANSELOW, MS;DECOLA, JP;YOUNG, SL
通讯作者：
YOUNG, SL