Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice.
Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice.
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DOI：
10.1016/j.neuropharm.2012.11.027
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发表时间：
2013-04
影响因子：
4.7
通讯作者：
Lucki I
中科院分区：
文献类型：
--
作者：
Balu DT;Turner JR;Brookshire BR;Hill-Smith TE;Blendy JA;Lucki I
MRL/MPJ小鼠表现出促进伤口愈合和组织再生，以及增加对慢性抗抑郁药物治疗的神经营养动员。这项研究比较了MRL/MPJ和C57BL/6J小鼠的脑单胺系统，作为慢性抗抑郁药物治疗后品系差异的潜在基础。MRL/MPJ小鼠在多个脑区的5-羟色胺和多巴胺的组织水平显著高于对照组。微透析研究表明，细胞外5-羟色胺的基线水平在不同菌株之间没有差异。然而，急性给予选择性5-羟色胺再摄取抑制剂西酞普兰后，MRL/MPJ小鼠腹侧海马区细胞外5-羟色胺含量增加，是C57BL/6J小鼠的两倍。在MRL/MPJ小鼠中，在局部灌流西酞普兰后，5-羟色胺水平的更大影响不能保持，这表明海马区外的机制是西酞普兰全身注射后产生更大效果的原因。MRL/MPJ小鼠海马区5-羟色胺和去甲肾上腺素转运体密度显著增加。此外，MRL/MPJ小鼠海马区5-HT1a基因的表达较低，5-HT1B基因在海马区和脑干的表达较高，SERT基因在脑干的表达较高。在MRL/MPJ小鼠中，神经递质释放的夸大伴随着尾部悬吊试验中基线不动的减少，以及西酞普兰或三环抗抑郁剂地昔帕明产生的不动更大的减少。这些数据表明，这两个菌株对急性和慢性抗抑郁药物治疗的反应差异可能归因于5-羟色胺或儿茶酚胺传递的不同。
The MRL/MpJ mouse demonstrates enhanced wound healing and tissue regeneration and increased neurotrophic mobilization to chronic antidepressant drug treatments. This study compared brain monoamine systems between MRL/MpJ and C57BL/6J mice as a potential basis for strain differences after chronic antidepressant treatment. MRL/MpJ mice had significantly higher tissue levels of serotonin and dopamine in multiple brain regions. Microdialysis studies demonstrated that baseline levels of extracellular serotonin did not differ between strains. However, acute administration of the selective serotonin reuptake inhibitor citalopram produced an increase in extracellular serotonin in the ventral hippocampus of MRL/MpJ mice that was twice as large as achieved in C57BL/6J mice. The greater effects in MRL/MpJ mice on 5-HT levels were not maintained after local perfusion of citalopram, suggesting that mechanisms outside of the hippocampus were responsible for the greater effect of citalopram after systemic injection. The density of serotonin and norepinephrine transporters in the hippocampus was significantly higher in MRL/MpJ mice. In addition, the expression of 5-HT1A mRNA was lower in the hippocampus, 5-HT1B mRNA was higher in the hippocampus and brain stem and SERT mRNA was higher in the brain stem of MRL/MpJ mice. The exaggerated neurotransmitter release in MRL/MpJ mice was accompanied by reduced baseline immobility in the tail suspension test and a greater reduction of immobility produced by citalopram or the tricyclic antidepressant desipramine. These data suggest that differences in the response to acute and chronic antidepressant treatments between the two strains could be attributed to differences in serotonin or catecholamine transmission.
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影响因子：
3.4
作者：
Lucki, I;Dalvi, A;Mayorga, AJ
通讯作者：
Mayorga, AJ
DOI：
10.1124/jpet.109.158717
发表时间：
2010-01-01
影响因子：
3.5
作者：
Hodes, Georgia E.;Hill-Smith, Tiffany E.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
8.2
作者：
Balu, Darrick T.;Lucki, Irwin
通讯作者：
Lucki, Irwin
DOI：
10.1098/rstb.2004.1468
发表时间：
2004-05-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Heber-Katz, E;Leferovich, J;Clark, L
通讯作者：
Clark, L
影响因子：
3.6
作者：
Gavioli, EC;Vaughan, CW;Calo', G
通讯作者：
Calo', G