The role of Western diets and obesity in peripheral immune cell recruitment and inflammation in the central nervous system.
The role of Western diets and obesity in peripheral immune cell recruitment and inflammation in the central nervous system.
复制标题
DOI：
10.1016/j.bbih.2021.100298
复制
发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Butler MJ
中科院分区：
文献类型：
--
作者：
Butler MJ
随着肥胖和慢性病患病率的增加，营养的作用不仅是代谢相关疾病的潜在根源，也是中枢神经系统(CNS)紊乱的潜在根源。摄入现代西化饮食，如含有过量饱和脂肪酸(SFA)、精制碳水化合物和超加工成分的高脂肪饮食(HFD)，已被证明在啮齿动物、非人类灵长类动物和人类的多个大脑区域诱发神经炎症，这些区域对能量平衡、认知功能和情绪调节至关重要。这篇综述文章综述了西方饮食通过增加SFA，可以提高免疫系统天然和适应性分支的多种免疫细胞的反应性和改变其功能的文献，尤其是小胶质细胞、巨噬细胞、树突状细胞和T细胞。免疫和神经免疫信号的这些变化对神经炎症和脑健康具有重要意义，并将成为未来心理神经免疫学研究的重要因素。
As the prevalence of obesity and chronic disease increases, the role of nutrition is taking center stage as a potential root cause of not just metabolic-related illnesses, but also of disorders of the central nervous system (CNS). Consumption of a modern, westernized diet, such as a high fat diet (HFD) that contains excess saturated fatty acids (SFAs), refined carbohydrates, and ultra-processed ingredients has been shown to induce neuroinflammation in multiple brain regions important for energy homeostasis, cognitive function, and mood regulation in rodents, non-human primates, and humans. This review article summarizes the literature showing Western diets, via SFA increases, can increase the reactivity and alter the function of multiple types of immune cells from both the innate and adaptive branches of the immune system, with a specific focus on microglia, macrophages, dendritic cells, and T-cells. These changes in immune and neuroimmune signaling have important implications for neuroinflammation and brain health and will be an important factor in future psychoneuroimmunology research.
登录
查看更多内容
DOI：
10.1016/j.bbalip.2019.04.001
发表时间：
2019-07-01
影响因子：
4.8
作者：
Gianfrancesco, Marco A.;Dehairs, Jonas;Legrand-Poels, Sylvie
通讯作者：
Legrand-Poels, Sylvie
影响因子：
4.7
作者：
DiSabato DJ;Quan N;Godbout JP
通讯作者：
Godbout JP
影响因子：
--
作者：
Coder B;Wang W;Wang L;Wu Z;Zhuge Q;Su DM
通讯作者：
Su DM
影响因子：
3.7
作者：
Chen, Yufan;Huang, Jiebin;Xu, Chundi
通讯作者：
Xu, Chundi
影响因子：
6.9
作者：
Hwang, Ling-Ling;Wang, Chien-Hua;Chiou, Lih-Chu
通讯作者：
Chiou, Lih-Chu