Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.
Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.
复制标题
DOI：
10.1093/braincomms/fcad069
复制
发表时间：
2023
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
意识障碍是由严重脑损伤引起的意识受损状态。先前的静息态功能磁共振成像研究报告了意识障碍患者在不同拓扑尺度下使用图论分析的异常脑网络特性。然而，目前还不清楚区域间定向传播活动如何影响意识障碍患者功能性脑网络的拓扑组织。为了揭示意识障碍患者拓扑结构的改变，我们结合功能连接分析和时间延迟估计构建了全脑定向功能网络。在此基础上，从节点尺度、静息态网络尺度和全局尺度三个拓扑尺度对有向功能脑网络进行了图论分析。最后，使用典型相关分析来确定意识障碍患者的拓扑性质改变与临床评分之间的相关性。在节点的规模，我们观察到减少的程度和增加的程度在楔前叶意识障碍患者。在静息态网络量表上，意识障碍患者在默认模式网络内以及默认模式网络与其他静息态网络之间表现出重组的基序模式。在全球范围内，我们发现一个较低的全球聚类系数的意识障碍患者比对照组。典型相关分析结果显示，异常程度和被破坏的基序与意识障碍患者的临床评分显著相关。我们的研究结果表明，意识障碍可以通过全脑多个拓扑尺度上的异常定向连接模式来揭示，并且中断的定向连接模式可以作为临床生物标志物来评估意识障碍患者的功能障碍。Guo等报道了基于多个拓扑尺度的定向功能脑网络的异常连接模式及其与意识障碍患者临床表现的相关性。研究结果表明，在多个尺度上的定向交互可能在维持意识方面发挥关键作用。
Disorders of consciousness are impaired states of consciousness caused by severe brain injuries. Previous resting-state functional magnetic resonance imaging studies have reported abnormal brain network properties at different topological scales in patients with disorders of consciousness by using graph theoretical analysis. However, it is still unclear how inter-regional directed propagation activities affect the topological organization of functional brain networks in patients with disorders of consciousness. To reveal the altered topological organization in patients with disorders of consciousness, we constructed whole-brain directed functional networks by combining functional connectivity analysis and time delay estimation. Then we performed graph theoretical analysis based on the directed functional brain networks at three topological scales, from the nodal scale, the resting-state network scale to the global scale. Finally, the canonical correlation analysis was used to determine the correlations between altered topological properties and clinical scores in patients with disorders of consciousness. At the nodal scale, we observed decreased in-degree and increased out-degree in the precuneus in patients with disorders of consciousness. At the resting-state network scale, the patients with disorders of consciousness showed reorganized motif patterns within the default mode network and between the default mode network and other resting-state networks. At the global scale, we found a lower global clustering coefficient in the patients with disorders of consciousness than in the controls. The results of the canonical correlation analysis showed that the abnormal degree and the disrupted motif were significantly correlated with the clinical scores of the patients with disorders of consciousness. Our findings showed that consciousness impairment can be revealed by abnormal directed connection patterns at multiple topological scales in the whole brain, and the disrupted directed connection patterns may serve as clinical biomarkers to assess the dysfunction of patients with disorders of consciousness. Guo et al. reported the abnormal connection patterns based on directed functional brain networks at multiple topological scales and their correlations with clinical performances for the patients with disorders of consciousness. The findings suggested that directed interactions at multiple scales may exert a crucial role in the maintenance of consciousness.
登录
查看更多内容
重新审视全球工作空间，策划人脑的等级组织。
影响因子：
29.9
作者：
Deco G;Vidaurre D;Kringelbach ML
通讯作者：
Kringelbach ML
DOI：
10.1038/s41582-020-00428-x
发表时间：
2021-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Edlow BL;Claassen J;Schiff ND;Greer DM
通讯作者：
Greer DM
影响因子：
9.9
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
通讯作者：
Pierelli, Francesco
DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bullmore, Edward T.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.
DOI：
10.1093/brain/awu132
发表时间：
2014-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Crossley NA;Mechelli A;Scott J;Carletti F;Fox PT;McGuire P;Bullmore ET
通讯作者：
Bullmore ET