The activity in the contralateral primary motor cortex, dorsal premotor and supplementary motor area is modulated by performance gains.
The activity in the contralateral primary motor cortex, dorsal premotor and supplementary motor area is modulated by performance gains.
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DOI：
10.3389/fnhum.2014.00201
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发表时间：
2014
影响因子：
2.9
通讯作者：
Karni A
中科院分区：
文献类型：
--
作者：
Sosnik R;Flash T;Sterkin A;Hauptmann B;Karni A
越来越多的实验证据表明，在一个给定的运动任务中，不同大脑区域的参与可能会随着练习而改变，尽管由运动学或动态表现指数定义的不同学习阶段背后的特定大脑活动模式还没有被很好地理解。在这里，我们研究了在练习笔迹样轨迹序列的过程中，运动区激活的变化，当躺在fMRI扫描仪中时，将数字化桌子上的四个靶点连接起来，以尽可能快和尽可能准确的速度。分析受试者在训练期开始、中期和结束时获得的运动学和成像数据，发现对侧M1、PM(背侧和腹侧)、辅助运动区(SMA)、SMA前区和后顶叶皮质(PPC)的激活量与练习本身的量之间没有相关性。单次试验分析表明，对侧M1的激活量和试验平均速度之间的相关性部分地受到与操作增益相关的影响的调节，例如增加了手的运动平稳性。此外，研究还发现，当受试者从产生直的点对点轨迹转移到时空连接成平滑、弯曲的轨迹时，对侧前SMA的激活量增加。总之，我们的结果表明，在学习动作序列的过程中，对侧M1、PMD和PreSMA的激活量与成绩相关，高水平的运动特征(例如，运动平稳性)可能调节甚至掩盖活动变化和低水平的运动属性(例如，试测平均速度)之间的相关性。
There is growing experimental evidence that the engagement of different brain areas in a given motor task may change with practice, although the specific brain activity patterns underlying different stages of learning, as defined by kinematic or dynamic performance indices, are not well understood. Here we studied the change in activation in motor areas during practice on sequences of handwriting-like trajectories, connecting four target points on a digitizing table “as rapidly and as accurately as possible” while lying inside an fMRI scanner. Analysis of the subjects' pooled kinematic and imaging data, acquired at the beginning, middle, and end of the training period, revealed no correlation between the amount of activation in the contralateral M1, PM (dorsal and ventral), supplementary motor area (SMA), preSMA, and Posterior Parietal Cortex (PPC) and the amount of practice per-se. Single trial analysis has revealed that the correlation between the amount of activation in the contralateral M1 and trial mean velocity was partially modulated by performance gains related effects, such as increased hand motion smoothness. Furthermore, it was found that the amount of activation in the contralateral preSMA increased when subjects shifted from generating straight point-to-point trajectories to their spatiotemporal concatenation into a smooth, curved trajectory. Altogether, our results indicate that the amount of activation in the contralateral M1, PMd, and preSMA during the learning of movement sequences is correlated with performance gains and that high level motion features (e.g., motion smoothness) may modulate, or even mask correlations between activity changes and low-level motion attributes (e.g., trial mean velocity).
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影响因子：
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作者：
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