Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging.
Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging.
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大脑区域葡萄糖代谢，神经精神症状和出现的风险轻度认知障碍：梅奥诊所的衰老研究。
DOI：
10.1016/j.jagp.2020.06.006
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Geda YE
中科院分区：
文献类型：
--
作者：
Krell-Roesch J;Syrjanen JA;Vassilaki M;Lowe VJ;Vemuri P;Mielke MM;Machulda MM;Stokin GB;Christianson TJ;Kremers WK;Jack CR Jr;Knopman DS;Petersen RC;Geda YE
我们进行了一项前瞻性队列研究，以检查基线神经精神症状(NPS)和大脑局部葡萄糖代谢功能障碍预测的轻度认知障碍(MCI)事件的风险。对1363例(52.8%男性)50岁的认知正常(CU)个体进行了中位数为4.8年的≥事件的随访。采用Beck抑郁与焦虑量表(BDI-II，BAI)和神经精神病学问卷对NPS进行评定。在阿尔茨海默病的典型受累区域，用FDGPET测量葡萄糖低代谢，并将其定义为SUVR≤1.47。COX比例风险模型根据年龄、性别、教育程度和载脂蛋白Eε4状态进行了调整。与对照组(区域糖代谢正常且无抑郁)相比，患有区域性葡萄糖代谢低下和抑郁(BDI-II≥13)的患者发生轻度脑梗塞的风险增加了三倍以上(HR[95%CI]，3.66[1.75，7.65]，p<；0.001，X2=11.83，df=1)，而患有葡萄糖代谢低下和焦虑的参与者(BAI≥10)的风险也显著增加(7.21[3.54，14.7]，p<；0.001，X2=29.68，df=1)。具有葡萄糖代谢低下和≥1 NPS(3.74[2.4，5.82]，p<；0.001，X2=34.13，df=1)或≥2 nps(3.89[2.20，6.86]，p<；0.001，X2=21.92，df=1)的患者发生轻度心肌梗死的风险增加3倍以上，≥3nps使风险增加4倍以上(4.12[2.03，8.37]，p<；0.001，X2=15.39，df=1)。NPS合并局部葡萄糖代谢低下与发生MCI的风险增加相关，FDG-PET似乎比NPS是认知功能下降的更强驱动力。
We conducted a prospective cohort study to examine the risk of incident mild cognitive impairment (MCI) as predicted by baseline neuropsychiatric symptoms (NPS) and brain regional glucose metabolic dysfunction. 1363 cognitively unimpaired (CU) individuals (52.8% males) aged ≥ 50 years were followed for a median of 4.8 years to the outcome of incident MCI. NPS were assessed using Beck Depression and Anxiety Inventories (BDI-II, BAI) and Neuropsychiatric Inventory Questionnaire. Glucose hypometabolism was measured by FDG-PET and defined as SUVR ≤ 1.47 in regions typically affected in Alzheimer’s disease. Cox proportional hazards models were adjusted for age, sex, education and APOE ε4 status. Participants with regional glucose hypometabolism and depression (BDI-II ≥ 13) had a more than threefold increased risk of incident MCI (HR [95% CI], 3.66 [1.75, 7.65], p < 0.001, X2 = 11.83, df = 1) as compared to the reference group (normal regional glucose metabolism and no depression), and the risk was also significantly elevated (7.21 [3.54, 14.7], p < 0.001, X2 = 29.68, df = 1) for participants with glucose hypometabolism and anxiety (BAI ≥ 10). Having glucose hypometabolism and ≥ 1 NPS (3.74 [2.40, 5.82], p < 0.001, X2 = 34.13, df = 1) or ≥ 2 NPS (3.89 [2.20, 6.86], p < 0.001, X2 = 21.92, df = 1) increased the risk of incident MCI by more than three times, and having ≥ 3 NPS increased the risk by more than four times (4.12 [2.03, 8.37], p < 0.001, X2 = 15.39, df = 1). Combined presence of NPS with regional glucose hypometabolism is associated with an increased risk of incident MCI, with FDG-PET appearing to be a stronger driving force of cognitive decline than NPS.
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基线神经精神症状和发生轻度认知障碍的风险：一项基于人群的研究。
DOI：
10.1176/appi.ajp.2014.13060821
发表时间：
2014-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Geda YE;Roberts RO;Mielke MM;Knopman DS;Christianson TJ;Pankratz VS;Boeve BF;Sochor O;Tangalos EG;Petersen RC;Rocca WA
通讯作者：
Rocca WA
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17.7
作者：
Alexander, GE;Chen, K;Reiman, EM
通讯作者：
Reiman, EM
影响因子：
5.7
作者：
Herholz, K;Salmon, E;Heiss, WD
通讯作者：
Heiss, WD
DOI：
10.1076/jcen.20.2.194.1173
发表时间：
1998-04-01
影响因子：
2.2
作者：
Lucas, JA;Ivnik, RJ;Petersen, RC
通讯作者：
Petersen, RC
DOI：
10.1016/j.jalz.2010.03.003
发表时间：
2010-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Bandy D;Chen K;Foster NL;Landau SM;Mathis CA;Price JC;Reiman EM;Skovronsky D;Koeppe RA;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative