Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study.
Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study.
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DOI：
10.3109/00365521.2013.822091
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发表时间：
2014-05
影响因子：
1.9
通讯作者：
Terasaka R
中科院分区：
文献类型：
--
作者：
Wang Z;Uchida K;Ohnaka K;Morita M;Toyomura K;Kono S;Ueki T;Tanaka M;Kakeji Y;Maehara Y;Okamura T;Ikejiri K;Futami K;Maekawa T;Yasunami Y;Takenaka K;Ichimiya H;Terasaka R
高糖饮食可能促进结直肠癌的发生，但尚不确定高糖或蔗糖的摄入是否会增加结直肠癌的风险。作者在日本的一项基于社区的病例对照研究中调查了糖和蔗糖摄入量与结直肠癌风险的关系。研究对象包括816例结肠直肠癌发病病例和815例社区对照。消费频率和148食品和饮料项目的部分大小确定了计算机辅助采访。作者使用29种食物的消费量来估计糖和蔗糖的摄入量。使用logistic回归模型校正潜在的混杂变量，获得了不同摄入类别的结直肠癌风险的比值比。总的来说，糖和蔗糖的摄入量与男性或女性的结直肠癌风险无关。糖摄入量与结直肠癌风险之间的关联因男性吸烟状况和饮酒而异，但女性则无此差异。在男性中，糖的摄入量往往与结直肠癌的风险呈负相关，在从不吸烟的男性中呈正相关（相互作用p = 0.01）。糖的摄入量与不饮酒男性的风险增加有关，但与男性饮酒者的风险无关（相互作用p = 0.02）。无论男性还是女性，体重指数都没有改变与糖摄入量的关联。在男性中，糖的摄入量与吸烟者和非饮酒者患结直肠癌的风险增加有关。
A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case–control study in Japan. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.
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影响因子：
5
作者：
WILLETT, W;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
254.7
作者：
Giovannucci, Edward;Harlan, David M.;Yee, Douglas
通讯作者：
Yee, Douglas
DOI：
10.1080/01635581.2012.690927
发表时间：
2012-01-01
影响因子：
2.9
作者：
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通讯作者：
Terasaka, Reiji
影响因子：
5.7
作者：
Yin, Guang;Kono, Suminori;Imaizumi, Nobutoshi
通讯作者：
Imaizumi, Nobutoshi
影响因子：
5.7
作者：
Isomura, Kayoko;Kono, Suminori;Imaizumi, Nobutoshi
通讯作者：
Imaizumi, Nobutoshi