Fluoxetine exposure throughout neurodevelopment differentially influences basilar dendritic morphology in the motor and prefrontal cortices.
Fluoxetine exposure throughout neurodevelopment differentially influences basilar dendritic morphology in the motor and prefrontal cortices.
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DOI：
10.1038/s41598-022-11614-w
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发表时间：
2022-05-09
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
许多类别的精神科药物的血清素作用强调了血清素 (5HT) 在心理健康中的重要性。众所周知，5HT 在神经发育中具有重要作用，因此发育过程中 5HT 的破坏可能会对大脑结构和回路产生长期影响。我们之前通过母亲给予选择性血清素再摄取抑制剂氟西汀，建立了整个神经发育过程中 5HT 改变的模型。我们发现后代在出生后和成年期间的社会行为发生了变化。其他人之前的工作表明，早期 5HT 破坏会影响神经元形态。因此，在当前的研究中，我们试图确定树突形态变化是否发生在我们之前观察到的涉及社会行为缺陷的区域，特别是初级运动皮质（M1）和内侧前额叶皮层（mPFC）。我们量化了暴露于氟西汀的小鼠出生后 (P)10 和 P79 天 M1 和 mPFC 中投射神经元的树突形态。在暴露于氟西汀的 M1 神经元中，基底树突复杂性和树突棘密度持续降低，而在 mPFC 中，在 P79 处观察到类似的降低，但在 P10 处不存在。我们的研究结果强调，发育中的大脑，特别是投射皮层，很容易受到 5HT 系统扰动的影响，这可能与后来的行为干扰有关。
The significance of serotonin (5HT) in mental health is underscored by the serotonergic action of many classes of psychiatric medication. 5HT is known to have a significant role in neurodevelopment, thus 5HT disruption during development may have a long term impact on brain structure and circuits. We previously generated a model of 5HT alteration throughout neurodevelopment by maternal administration of the selective serotonin reuptake inhibitor fluoxetine. We found resulting social behavior alterations in the offspring during both postnatal and adult ages. Previous work by others has indicated that early 5HT disruption influences neuronal morphology. Therefore, in the current study we sought to determine if dendritic morphological changes occur in areas involved in the social behavior deficits we previously observed, specifically the primary motor (M1) and medial prefrontal (mPFC) cortices. We quantified dendritic morphology of projection neurons in M1 and mPFC at postnatal day (P)10 and P79 in mice exposed to fluoxetine. Basilar dendritic complexity and spine density were persistently decreased in M1 fluoxetine-exposed neurons while in the mPFC, similar reductions were observed at P79 but were not present at P10. Our findings underscore that the developing brain, specifically the projection cortex, is vulnerable to 5HT system perturbation, which may be related to later behavioral disruptions.
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影响因子：
10.6
作者：
Lucki, I
通讯作者：
Lucki, I
DOI：
10.9758/cpn.2014.12.3.196
发表时间：
2014-12
期刊：
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
影响因子：
--
作者：
Lin SH;Lee LT;Yang YK
通讯作者：
Yang YK
影响因子：
5.3
作者：
Celada, P;Puig, MV;Artigas, F
通讯作者：
Artigas, F
影响因子：
3
作者：
Ko, Meng-Ching;Lee, Lukas Jyuhn-Hsiarn;Lee, Li-Jen
通讯作者：
Lee, Li-Jen
影响因子：
2.3
作者：
Muhammad, Arif;Mychasiuk, Richelle;Kolb, Bryan
通讯作者：
Kolb, Bryan