Race/ethnic disparities in reproductive age: an examination of ovarian reserve estimates across four race/ethnic groups of healthy, regularly cycling women.
Race/ethnic disparities in reproductive age: an examination of ovarian reserve estimates across four race/ethnic groups of healthy, regularly cycling women.
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DOI：
10.1016/j.fertnstert.2013.09.015
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发表时间：
2014-01
影响因子：
6.7
通讯作者：
Cedars MI
中科院分区：
文献类型：
--
作者：
Bleil ME;Gregorich SE;Adler NE;Sternfeld B;Rosen MP;Cedars MI
To determine whether reproductive age, indexed by a validated marker of ovarian reserve (antimüllerian hormone [AMH]), varies between women of different race/ethnic backgrounds. Cross-sectional study. Community-based sample. Multi-ethnic sample of 947 (277 white, 237 African-American, 220 Latina, and 213 Chinese) healthy and regularly-cycling pre-menopausal women, ages 25-45. None. AMH level. A multivariate model was fit examining race/ethnicity, covariates, non-linear terms for age (age2, age3) and BMI (BMI2, BMI3), and 2-way interactions between race/ethnicity and each other predictor variable in relation to AMH. Following backward elimination, significant effects included race/ethnicity (F=8.45), age (F=349.94), race/ethnicity-by-linear age interaction (F=4.67), age2 (F=31.61), and BMI (F=10.69). Inspection of the significant race/ethnicity-by-linear age interaction showed AMH levels were consistently lower in the Latina vs. white women across all ages, whereas AMH levels were lower in the African-American and Chinese women vs. white women at younger and middle ages, respectively, and AMH levels were higher in the African-American vs. Latina and Chinese women at older ages. Although results must be considered preliminary, findings are two-fold, suggesting 1) African-American women may have lower AMH levels at younger ages but experience less of a reduction in AMH with advancing age; and 2) Latina and Chinese women, compared to white women, may have lower AMH levels, marking a lower ovarian reserve and possible increased risk for earlier menopause.
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