"Tell Juliana": acceptability of the candidate microbicide VivaGel® and two placebo gels among ethnically diverse, sexually active young women participating in a phase 1 microbicide study.
"Tell Juliana": acceptability of the candidate microbicide VivaGel® and two placebo gels among ethnically diverse, sexually active young women participating in a phase 1 microbicide study.
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DOI：
10.1007/s10461-011-0028-6
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发表时间：
2012-10
影响因子：
4.4
通讯作者：
McGowan, Ian
中科院分区：
文献类型：
--
作者：
Carballo-Dieguez, Alex;Giguere, Rebecca;Dolezal, Curtis;Chen, Beatrice A.;Kahn, Jessica;Zimet, Greg;Mabragana, Marina;Leu, Cheng-Shiun;McGowan, Ian
本研究评估了三个地点的 61 名性活跃的美国和波多黎各年轻女性对候选杀菌剂 VivaGel® 和两种安慰剂凝胶的可接受性。参与者被随机分配使用其中一种凝胶，每天两次，持续 14 天。试验完成时，VivaGel® 组中 59% 的女性表示将来可能会使用该凝胶，而 23% 的女性不太可能使用它，18% 的女性尚未决定。参与者报告了所有三种凝胶的问题，包括含有羟乙基纤维素（HEC）的“通用”安慰剂。最常见的投诉是泄露、干扰性行为和性满意度下降。有些投诉并不新鲜，但仍未得到解决。女性感知到的艾滋病毒感染风险可能决定是否使用凝胶。用户可能还需要选择粘度。阴道杀菌剂制剂的可接受性差可能会导致功效试验期间对凝胶使用的依从性差，并影响结果的有效性。
This study assessed acceptability of the candidate microbicide VivaGel® and two placebo gels among 61 sexually active young US and Puerto Rican women at three sites. Participants were randomly assigned to use one of the gels twice per day for 14 days. At trial completion, 59% of the women in the VivaGel® group reported being likely to use the gel in the future, whereas 23% were unlikely to use it and 18% were undecided. Participants reported problems with all three gels, including the “universal” placebo containing hydroxyethyl cellulose (HEC). The most frequent complaints were leakage, interference with sexual behavior, and decreased sexual satisfaction. Some of the complaints are not new but remain unresolved. Women’s perceived risk of HIV infection may determine whether the gels are used. Users also may want a choice of viscosity. Poor acceptability of vaginal microbicide formulations may result in poor adherence to gel use during efficacy trials and compromise validity of results.
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影响因子：
5
作者：
Leynaert, B;Downs, AM;de Vincenzi, I
通讯作者：
de Vincenzi, I
DOI：
10.1080/09540120601133576
发表时间：
2007-07-01
影响因子：
1.7
作者：
Joglekar, N.;Joshi, S.;Mehendale, S.
通讯作者：
Mehendale, S.
DOI：
10.1126/science.1193748
发表时间：
2010-09-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abdool Karim Q;Abdool Karim SS;Frohlich JA;Grobler AC;Baxter C;Mansoor LE;Kharsany AB;Sibeko S;Mlisana KP;Omar Z;Gengiah TN;Maarschalk S;Arulappan N;Mlotshwa M;Morris L;Taylor D;CAPRISA 004 Trial Group
通讯作者：
CAPRISA 004 Trial Group
DOI：
10.2307/2648235
发表时间：
2000-07-01
期刊：
FAMILY PLANNING PERSPECTIVES
影响因子：
--
作者：
Bentley, ME;Morrow, KM;Mayer, KH
通讯作者：
Mayer, KH
DOI：
10.1097/00002030-199601001-00011
发表时间：
1996-01-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
Mastro, T D;de Vincenzi, I
通讯作者：
de Vincenzi, I