The Drosophila IMD pathway in the activation of the humoral immune response.

The Drosophila IMD pathway in the activation of the humoral immune response.
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DOI:
10.1016/j.dci.2013.05.014
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发表时间:
2014-01
影响因子:
2.9
通讯作者:
Silverman, Neal
Silverman, Neal
中科院分区:
生物学3区
文献类型:
--
作者:
Kleino, Anni;Silverman, Neal

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IMD信号通路在果蝇防御细菌中起着关键作用。在过去的二十年中,在鉴定该途径的组分和破译该途径的分子机制方面取得了重大进展,包括细菌传感和信号转导的手段。这些发现不仅有助于理解昆虫的免疫信号,也为研究哺乳动物NF-κB信号通路提供了新的视角。在这里,我们总结了目前的IMD途径的观点,重点是它如何调节果蝇的体液免疫反应。
The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-κB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.
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