Development of a Microelectrode Array Sensing Platform for Combination Electrochemical and Spectrochemical Aqueous Ion Testing.
Development of a Microelectrode Array Sensing Platform for Combination Electrochemical and Spectrochemical Aqueous Ion Testing.
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DOI：
10.1016/j.snb.2008.10.031
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发表时间：
2009-02-02
影响因子：
8.4
通讯作者：
Zufelt, Nephi A.
中科院分区：
文献类型：
--
作者：
Gardner, Robert D.;Zhou, Anhong;Zufelt, Nephi A.
关键词：
设计和制造了一个微电极阵列传感器平台，以增加多样性，灵活性和测试能力的通用性，超过传统报道的传感器平台。这些新的传感器平台由18个单独的可寻址微电极组成，采用光刻技术制造，采用玻璃基板和抗蚀聚合物层作为绝缘剂，以保护传感器的电路和布线免受不希望的溶液相互作用。可单独寻址的微电极通过允许电极之间的隔离电化学测试、全局阵列测试或电极的某些组合来执行电化学方法，从而增加了多样性。此外，由于玻璃基板和抗蚀剂掩膜层的光学透明性，以及电极阵列的小尺寸，光谱化学分析可以在作为电化学电池和试管的样品区域内进行，而微电极阵列在光谱化学测试过程中被动地驻留在光程长度内。这种独特的安排为各种应用提供了改进的测试可能性，包括环境测试中的同时电化学和光谱化学分析，生物技术领域中生物利用度可能物种的鉴定或定量，以及工业应用中的过程控制。用铁氰化钾（一种电化学标准分析物）验证了传感器平台的电化学特性和光谱分析用途，并将电化学测量结果与市售的类似尺寸的工作电极进行了比较。此外，利用传感器平台进行了差分脉冲阳极溶出伏安法电化学方法，以检测水溶液中的铜和铅重金属离子，证明了该方法在环境样品中的应用潜力。
A microelectrode array sensor platform was designed and fabricated to increase diversity, flexibility, and versatility of testing capabilities over that of traditionally reported sensor platforms. These new sensor platforms consist of 18 individual addressable microelectrodes, photolithography fabricated, that employ a glass base substrate and a resist polymer layer that acts as an insulating agent to protect the circuitry and wiring of the sensor from undesired solution interactions. Individually addressable microelectrodes increase diversity by allowing isolated electrochemical testing between electrodes, global array testing, or some combination of electrodes to perform electrochemical methods. Furthermore, because of the optical transparency of the glass base substrate and the resist mask layer, along with the small size of the electrode array, spectrochemical analysis is possible within the sample area that acts as electrochemical cell and cuvette, while the microelectrode array passively resides within the optical path length during spectrochemical testing. This unique arrangement offers improved testing possibilities for various applications, including simultaneous electrochemical and spectrochemical analysis in environmental testing, identification or quantification of possible species for bioavailability in the biotechnology field, and process control in industrial applications. Electrochemical characteristics and spectrochemcial use of the sensor platform are proven with potassium ferricyanide, an electrochemical standard analyte, and electrochemical measurements are compared against a commercially available working electrode of similar size. Additionally, the electrochemical method of differential pulse anodic stripping voltammetry is performed with the sensor platform to detect copper and lead heavy metal ions in aqueous solution, demonstrating the potential for use with environmental samples.
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影响因子：
7.4
作者：
FORSBERG, G;OLAUGHLIN, JW;KOIRTYOHANN, SR
通讯作者：
KOIRTYOHANN, SR
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通讯作者：
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