Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors.
Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors.
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DOI：
10.1002/ijc.30292
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发表时间：
2017-01-15
影响因子：
6.4
通讯作者：
Schüz J
中科院分区：
文献类型：
--
作者：
McCormack VA;Menya D;Munishi MO;Dzamalala C;Gasmelseed N;Leon Roux M;Assefa M;Osano O;Watts M;Mwasamwaja AO;Mmbaga BT;Murphy G;Abnet CC;Dawsey SM;Schüz J
食管鳞状细胞癌（ESCC）是大多数东部和南部非洲国家最常见的癌症之一，但迄今为止对其病因的研究还不够。为了告知其研究议程，我们进行了一项审查，以确定在世界范围内已经确定或强烈建议的ESCC风险因素，在任何受ESCC影响的非洲环境中具有高患病率或高暴露水平的风险因素及其来源。我们发现，对于迄今为止已知的几乎所有ESCC风险因素，包括烟草，酒精，热饮消费，亚硝胺以及吸入和摄入的多环芳烃，有证据表明人口群体的暴露量增加，其来源在ESCC走廊的文化之间差异很大。有必要对这些危险因素进行研究，并有可能确定初级预防战略。
Oesophageal squamous cell carcinoma (ESCC) is one of the most common cancers in most Eastern and Southern African countries, but its aetiology has been understudied to date. To inform its research agenda, we undertook a review to identify, of the ESCC risk factors that have been established or strongly suggested worldwide, those with a high prevalence or high exposure levels in any ESCC-affected African setting and the sources thereof. We found that for almost all ESCC risk factors known to date, including tobacco, alcohol, hot beverage consumption, nitrosamines and both inhaled and ingested PAHs, there is evidence of population groups with raised exposures, the sources of which vary greatly between cultures across the ESCC corridor. Research encompassing these risk factors is warranted and is likely to identify primary prevention strategies.
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影响因子：
8.8
作者：
BRADSHAW, E;SCHONLAND, M
通讯作者：
SCHONLAND, M
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作者：
Bhat, Gulzar Ahmad;Shah, Idrees Ayoub;Dar, Nazir Ahmad
通讯作者：
Dar, Nazir Ahmad
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Cheng, Michael L.;Zhang, Li;Van Loon, Katherine
通讯作者：
Van Loon, Katherine
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通讯作者：
Boffetta, Paolo
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Duron, V;Bii, J.;White, R.
通讯作者：
White, R.