Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions.
Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions.
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Homer信号通路作为缺血性和创伤性脑损伤和视网膜病变的有效治疗靶点
DOI：
10.4103/1673-5374.330588
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发表时间：
2022-07
影响因子：
6.1
通讯作者：
Fei F
中科院分区：
文献类型：
--
作者：
Wu XQ;Su N;Fei Z;Fei F
缺血性和创伤性中枢神经系统损伤是最严重的急性和致命脑损伤，通常以原发性和继发性损伤为特征。继发性损伤是医务人员面临的最大挑战；然而，目前对继发性损伤的有效治疗靶点很少。Homer蛋白是一种突触后支架蛋白，与中枢神经系统的缺血性和创伤性损伤有关。在这种侮辱中，Homer信号可以发挥积极或消极的作用，这取决于Homer蛋白的特定亚型。homer1b /c与其他蛋白偶联形成突触后密度，构成突触传递的基础，而Homer1a的表达可被外界有害因素诱导。Homer 1c被用作一种独特的生物标志物，用于揭示视网膜神经节细胞凋亡之前和早期阶段突触连通性的改变，这种改变是由细胞外或细胞内信号传导或细胞骨架过程介导或影响的。本文就Homer蛋白的结构特点、相关信号通路及其在生理病理过程中的多种作用作一综述。上调Homer1a或下调Homer1b/c可能在继发性脑损伤中发挥神经保护作用。Homer在光感受器突触的形成中也起着重要作用。这些发现证实了Homer的神经保护作用，并支持未来基于Homer蛋白设计缺血性和创伤性脑损伤和视网膜疾病的治疗药物靶点或基因疗法。
Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary damage. Secondary damage presents the greatest challenge for medical staff; however, there are currently few effective therapeutic targets for secondary damage. Homer proteins are postsynaptic scaffolding proteins that have been implicated in ischemic and traumatic insults to the central nervous system. Homer signaling can exert either positive or negative effects during such insults, depending on the specific subtype of Homer protein. Homer 1b/c couples with other proteins to form postsynaptic densities, which form the basis of synaptic transmission, while Homer1a expression can be induced by harmful external factors. Homer 1c is used as a unique biomarker to reveal alterations in synaptic connectivity before and during the early stages of apoptosis in retinal ganglion cells, mediated or affected by extracellular or intracellular signaling or cytoskeletal processes. This review summarizes the structural features, related signaling pathways, and diverse roles of Homer proteins in physiological and pathological processes. Upregulating Homer1a or downregulating Homer1b/c may play a neuroprotective role in secondary brain injuries. Homer also plays an important role in the formation of photoreceptor synapses. These findings confirm the neuroprotective effects of Homer, and support the future design of therapeutic drug targets or gene therapies for ischemic and traumatic brain injuries and retinal disorders based on Homer proteins.
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影响因子：
5.5
作者：
Ahumada-Castro U;Bustos G;Silva-Pavez E;Puebla-Huerta A;Lovy A;Cárdenas C
通讯作者：
Cárdenas C
影响因子：
2.5
作者：
Brandstätter, JH;Dick, O;Boeckers, TM
通讯作者：
Boeckers, TM
DOI：
10.1016/bs.pmbts.2015.06.013
发表时间：
2015
影响因子：
--
作者：
Chakraborty R;Pardue MT
通讯作者：
Pardue MT
影响因子：
6.1
作者：
Huang W;Liu X;Fei Z;Zhang Y;Yang J
通讯作者：
Yang J
DOI：
10.1016/j.bbamcr.2021.118947
发表时间：
2021-04
期刊：
Biochimica et biophysica acta. Molecular cell research
影响因子：
--
作者：
Docampo R;Huang G
通讯作者：
Huang G