Ribonucleases and bacterial virulence.
Ribonucleases and bacterial virulence.
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DOI：
10.1111/j.1751-7915.2010.00212.x
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发表时间：
2011-09
影响因子：
5.7
通讯作者：
Rosenzweig JA
中科院分区：
文献类型：
--
作者：
Lawal A;Jejelowo O;Chopra AK;Rosenzweig JA
细菌应激反应为它们提供了在恶劣环境中生存、繁殖并可能导致人类和动物疾病的机会。病原菌与宿主免疫细胞相互作用的方式触发了一系列复杂的事件，包括响应所遇到的各种宿主条件的快速遗传重新编程。从这个角度来看，细菌宿主细胞诱导的应激反应（HCISR）类似于任何其他表征良好的环境应激，细菌必须通过上调一组特定的应激反应基因来响应。应激后，细菌必须恢复其应激前的遗传程序，因此，必须通过RNA衰变机制降解不必要的应激反应转录物。此外，几种核糖核酸酶在冷休克反应中具有公认的作用，它们调节变化的转录物景观以响应应激，以及在适应和随后的应激后遗传重编程期间。最近，核糖核酸酶被认为是几种著名的革兰氏阴性病原体中的毒力相关因子，包括耶尔森氏菌、沙门氏菌、幽门螺杆菌、福氏志贺菌和嗜水气单胞菌。本文将重点介绍核糖核酸酶在细菌毒力、其他细菌应激反应中所起的作用，以及它们在治疗中的新应用。
Bacterial stress responses provide them the opportunity to survive hostile environments, proliferate and potentially cause diseases in humans and animals. The way in which pathogenic bacteria interact with host immune cells triggers a complicated series of events that include rapid genetic re‐programming in response to the various host conditions encountered. Viewed in this light, the bacterial host‐cell induced stress response (HCISR) is similar to any other well‐characterized environmental stress to which bacteria must respond by upregulating a group of specific stress‐responsive genes. Post stress, bacteria must resume their pre‐stress genetic program, and, as a consequence, must degrade unnecessary stress responsive transcripts through RNA decay mechanisms. Further, there is a well‐established role for several ribonucleases in the cold shock response whereby they modulate the changing transcript landscape in response to the stress, and during acclimation and subsequent genetic re‐programming post stress. Recently, ribonucleases have been implicated as virulence‐associated factors in several notable Gram‐negative pathogens including, the yersiniae, the salmonellae, Helicobacter pylori, Shigella flexneri and Aeromonas hydrophila. This review will focus on the roles played by ribonucleases in bacterial virulence, other bacterial stress responses, and on their novel therapeutic applications.
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影响因子：
5
作者：
Ardelt, Wojciech;Ardelt, Barbara;Darzynkiewicz, Zbigniew
通讯作者：
Darzynkiewicz, Zbigniew
影响因子：
3.6
作者：
Bugrysheva, Julia V.;Scott, June R.
通讯作者：
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影响因子：
3.6
作者：
Goverde, RLJ;Veld, JHJHI;Mooi, FR
通讯作者：
Mooi, FR
影响因子：
56.9
作者：
GRUNBERGMANAGO, M;ORTIZ, PJ;OCHOA, S
通讯作者：
OCHOA, S
影响因子：
10.5
作者：
Boisset, Sandrine;Geissmann, Thomas;Romby, Pascale
通讯作者：
Romby, Pascale