Risk of acute gastroenteritis associated with human bocavirus infection in children: A systematic review and meta-analysis.
Risk of acute gastroenteritis associated with human bocavirus infection in children: A systematic review and meta-analysis.
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儿童与人类博卡病毒感染相关的急性胃肠炎风险：系统评价和荟萃分析
DOI：
10.1371/journal.pone.0184833
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
De R;Liu L;Qian Y;Zhu R;Deng J;Wang F;Sun Y;Dong H;Jia L;Zhao L
人类博卡病毒（hbov）于2005年首次被发现，由基因型1-4组成，在全球急性胃肠炎患儿中越来越多地被发现。为了研究HBoV感染是否是5岁以下儿童急性胃肠炎的危险因素，我们检索了PubMed， Embase（通过Ovid），中国生物医学文献数据库（CBM）和Cochrane图书馆，以评估2005年10月25日至2016年10月31日个体HBoV患病率的研究。我们纳入了对患有或不患有急性胃肠炎的患者粪便标本中hbov进行pcr诊断的研究，这些研究对5岁以下的儿童患者进行了超过1年的研究。主要结果是所有急性胃肠炎病例的HBoV患病率。然后通过拟合线性混合效应元回归模型产生HBoV患病率的汇总估计。在纳入的36项研究中，20,591例急性胃肠炎患者的HBoV总患病率为6.90%（95%可信区间（95% CI）： 5.80-8.10%）。在10项有对照组的研究中，3620例急性胃肠炎患儿中有12.40%检测到hbov，而在2030例对照患儿中有12.22%检测到hbov(优势比（OR）： 1.44；95% CI: 0.95-2.19，病例组和对照组之间p = 0.09)。急性胃肠炎患儿中分别检出3.49%和8.59%的HBoV1和HBoV2，对照患儿中分别检出2.22%和5.09%的HBoV1和HBoV2 （OR: 1.40; 95% CI: 0.61-3.25; p = 0.43和OR: 1.68; 95% CI: 1.21-2.32; p = 0.002）。目前的证据表明，5岁以下儿童的HBoV总体流行率在患有或不患有急性胃肠炎的两组之间没有显著差异。然而，当排除HBoV1后，两组间HBoV2患病率有显著差异，这可能提示HBoV2是5岁以下儿童急性胃肠炎的危险因素。
Human bocaviruses (HBoVs), which were first identified in 2005 and are composed of genotypes 1–4, have been increasingly detected worldwide in pediatric patients with acute gastroenteritis. To investigate if HBoV infection is a risk factor of acute gastroenteritis in children younger than 5 years old, we searched PubMed, Embase (via Ovid), the Chinese Biomedical Literature Database (CBM), and the Cochrane Library for studies assessing the prevalence of HBoVs in individuals from Oct 25, 2005 to Oct 31, 2016. We included studies using PCR-based diagnostics for HBoVs from stool specimens of patients with or without acute gastroenteritis that carried out research for over 1 year on pediatric patients aged younger than 5 years old. The primary outcome was the HBoV prevalence among all cases with acute gastroenteritis. Pooled estimates of the HBoV prevalence were then generated by fitting linear mixed effect meta-regression models. Of the 36 studies included, the pooled HBoV prevalence in 20,591 patients with acute gastroenteritis was 6.90% (95% confidence interval (95% CI): 5.80–8.10%). In the ten studies with a control group, HBoVs were detected in 12.40% of the 3,620 cases with acute gastroenteritis and in 12.22% of the 2,030 control children (odds ratio (OR): 1.44; 95% CI: 0.95–2.19, p = 0.09 between case and control groups). HBoV1 and HBoV2 were detected in 3.49% and 8.59% of acute gastroenteritis cases, respectively, and in 2.22% and 5.09% of control children, respectively (OR: 1.40; 95% CI: 0.61–3.25; p = 0.43 and OR: 1.68; 95% CI: 1.21–2.32; p = 0.002, respectively). Current evidence suggests that the overall HBoV prevalence in children younger than 5 years old is not significantly different between groups with or without acute gastroenteritis. However, when HBoV1 was excluded, the HBoV2 prevalence was significantly different between these two groups, which may imply that HBoV2 is a risk factor of acute gastroenteritis in children younger than 5 years old.
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DOI：
10.1086/652416
发表时间：
2010-06-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Kapoor A;Simmonds P;Slikas E;Li L;Bodhidatta L;Sethabutr O;Triki H;Bahri O;Oderinde BS;Baba MM;Bukbuk DN;Besser J;Bartkus J;Delwart E
通讯作者：
Delwart E
影响因子：
3.7
作者：
Shang X;Fu X;Zhang P;Sheng M;Song J;He F;Qiu Y;Wu H;Lu Q;Feng Y;Lin J;Chen E;Chai C
通讯作者：
Chai C
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B
DOI：
10.1016/s1473-3099(14)70767-4
发表时间：
2014-08
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Ahmed SM;Hall AJ;Robinson AE;Verhoef L;Premkumar P;Parashar UD;Koopmans M;Lopman BA
通讯作者：
Lopman BA
影响因子：
2.2
作者：
DerSimonian R;Laird N
通讯作者：
Laird N