Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections.
Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections.
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DOI：
10.1086/652416
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Delwart E
中科院分区：
文献类型：
--
作者：
Kapoor A;Simmonds P;Slikas E;Li L;Bodhidatta L;Sethabutr O;Triki H;Bahri O;Oderinde BS;Baba MM;Bukbuk DN;Besser J;Bartkus J;Delwart E
对一种新的细小病毒进行了遗传鉴定，暂定名为人bocavir4 （HBoV4）。在641份儿童和成人粪便样本中，检出最多的bocavavirus种类依次为HBoV2、HBoV3、HBoV4和HBoV1，其中尼日利亚和突尼斯儿童的HBoV2感染率分别为21%和26%。在突尼斯和尼日利亚的192例非脊髓灰质炎急性弛缓性麻痹患者中，有12例检测到HBoV3或HBoV4，而在突尼斯的96例健康接触者中，0例检测到HBoV3或HBoV4 （P= 0.01）。发现了bocavavirus物种之间和物种内部在NP1和VP1基因边界处广泛重组的证据。与高度同质的HBoV1相比，在粪便标本中发现的人类bocavavirus具有高度的遗传多样性，这表明这种分布在世界各地的呼吸道病原体可能是在获得有利于呼吸道的扩大倾向后，最近从肠道bocavavirus进化而来的。阐明新发现的肠道bocavavirus在包括急性弛缓性麻痹和腹泻在内的人类疾病中的可能作用，将需要进一步的流行病学研究。
A new species of parvovirus, tentatively named human bocavirus 4 (HBoV4), was genetically characterized. Among 641 feces samples obtained from children and adults, the most commonly detected bocavirus species were, in descending order, HBoV2, HBoV3, HBoV4, and HBoV1, with an HBoV2 prevalence of 21% and 26% in Nigerian and Tunisian children, respectively. HBoV3 or HBoV4 species were found in 12 of 192 patients with non-polio acute flaccid paralysis in Tunisia and Nigeria and 0 of 96 healthy Tunisian contacts (P= .01). Evidence of extensive recombination at the NP1 and VP1 gene boundary between and within bocavirus species was found. The high degree of genetic diversity seen among the human bocaviruses found in feces specimens, relative to the highly homogeneous HBoV1, suggest that this worldwide-distributed respiratory pathogen may have recently evolved from an enteric bocavirus after acquiring an expanded tropism favoring the respiratory tract. Elucidating the possible role of the newly identified enteric bocaviruses in human diseases, including acute flaccid paralysis and diarrhea, will require further epidemiological studies.
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影响因子：
5.4
作者：
LEDERMAN, M;PATTON, JT;BATES, RC
通讯作者：
BATES, RC
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B
影响因子：
6.4
作者：
Lee, Jae In;Chung, Ju-Young;Hwang, Eung-Soo
通讯作者：
Hwang, Eung-Soo
影响因子：
11.8
作者：
Kantola, Kalle;Hedman, Lea;Soderlund-Venermo, Maria
通讯作者：
Soderlund-Venermo, Maria
影响因子：
11.8
作者：
Chieochansin T;Kapoor A;Delwart E;Poovorawan Y;Simmonds P
通讯作者：
Simmonds P