Exploring the molecular basis of addiction: drug-induced neuroadaptations.
Exploring the molecular basis of addiction: drug-induced neuroadaptations.
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DOI：
10.1038/npp.2009.106
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发表时间：
2010-01
期刊：
影响因子：
--
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中枢神经系统中的神经精神药理学信息。此外，这个大脑区域发送和接收来自中脑边缘多巴胺系统的投射，这些投射经常与成瘾有关(Bannerman等人，2004年)。此外，海马体被直接牵连到成瘾行为中(Vorel等人，2001)，可能是因为越来越多的证据表明，药物成瘾是一种条件性现象，在很大程度上依赖于药物效应和环境线索之间的关联(Berke和Hyman，2000)。海马体/伏隔核协调调节可能是环境丰富产生的保护性成瘾表型的核心。我们发现，与隔离对照组的大鼠相比，在丰富的条件下饲养的大鼠(有队列和新物体的大笼子)自我给予可卡因或苯丙胺的可能性较小(Green等人，2009年)。这种保护表型可能是通过伏隔核内cAMP反应元件结合蛋白(CREB)活性的协调降低和海马区的增加来调节的。此外，CREB与神经元的兴奋性有关(董等人，2006年)，这表明一些尚未确定的CREB靶基因可能通过降低伏隔区的兴奋性和增加海马区的兴奋性来产生这种保护性表型。
Neuropsychopharmacology information in the central nervous system. In addition, this brain region sends and receives projections from the mesolimbic dopamine system so often implicated in addiction (Bannerman et al, 2004). Further, the hippocampus has been directly implicated in addiction behavior (Vorel et al, 2001), likely because of the fact that there is increasing evidence suggesting that drug addiction represents a conditioning phenomenon that is largely dependent on associations between drug effects and environmental cues (Berke and Hyman, 2000).Coordinated hippocampal/accumbal regulation is likely at the heart of the protective addiction phenotype produced by environmental enrichment. We find that rats reared in an enriched condition (large cages with cohorts and novel objects) self-administer cocaine or amphetamine less readily than rats in the isolated control group (Green et al, 2009). This protective phenotype is likely mediated by a coordinated decrease in cAMP response element binding protein (CREB) activity in the accumbens coupled with an increase in the hippocampus. Further, CREB has been linked to neuronal excitability (Dong et al, 2006), suggesting that some yet to be identified CREB target gene may produce this protective phenotype by decreasing excitability in the accumbens and increasing excitability in the hippocampus.
影响因子：
7
作者：
Moron, Jose A.;Abul-Husn, Noura S.;Devi, Lakshmi A.
通讯作者：
Devi, Lakshmi A.
影响因子：
25
作者：
Dong, Y;Green, T;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
56.9
作者：
Vorel, SR;Liu, XH;Gardner, EL
通讯作者：
Gardner, EL