The Terneuzen Birth Cohort: BMI change between 2 and 6 years is most predictive of adult cardiometabolic risk.
The Terneuzen Birth Cohort: BMI change between 2 and 6 years is most predictive of adult cardiometabolic risk.
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Terneuzen 出生队列：2 至 6 年间的 BMI 变化最能预测成人心脏代谢风险。
DOI：
10.1371/journal.pone.0013966
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发表时间：
2010-11-12
期刊：
影响因子：
3.7
通讯作者：
Hirasing RA
中科院分区：
文献类型：
--
作者：
de Kroon ML;Renders CM;van Wouwe JP;van Buuren S;Hirasing RA
我们最近报道，2 - 6岁的年龄间隔是最早和最关键的成人超重。我们现在的目标是确定哪些年龄段可以预测年轻人的心脏代谢风险。我们分析了来自泰尔诺伊岑出生队列的642名18 - 28岁的患者的数据。采用分段线性模型拟合个体BMI SDS轨迹。通过多元回归分析，评估了随后的条件BMI SDS变化与代谢综合征（MetS）、皮褶厚度和青年期hsCRP组分之间的关系。结果根据性别、年龄和其他混杂因素进行了调整。性别作为一个影响因素进行了研究。整个儿童期的BMI SDS变化与腰围和皮褶厚度有关。除BMI SDS 0 - 1年变化与hsCRP之间存在相关性外，2岁以前未发现其他显著相关性。任何BMI SDS变化均不能预测空腹血糖。BMI SDS变化2 - 6年与大多数结果变量密切相关，尤其是腰围（0.47，SE 0.02）、收缩压和舒张压（0.20 SE 0.04和0.19 SE 0.03）和hsCRP（0.16 SE 0.04）。10 - 18岁时BMI SDS变化与HDL胆固醇（HDL-0.10，SE 0.03）和甘油三酯（TG-0.21，SE 0.03）的相关性最强。在较小程度上，BMI SDS变化6 - 10年与大多数结局变量相关。2 - 6年和10 - 18年BMI SDS变化与MetS显著相关：OR分别为3.39（95%CI 2.33 - 4.94）和2.84（95%CI 1.94 - 4.15）。BMI SDS从2岁起的变化与青年期的心脏代谢风险相关，2 - 6岁的年龄间隔是最具预测性的。监测和稳定2 - 6岁儿童的BMI SDS不仅可以逆转成人超重的进展，而且还可以保护心脏代谢状态。
We recently reported the age interval 2–6y being the earliest and most critical for adult overweight. We now aim to determine which age intervals are predictive of cardiometabolic risk at young adulthood. We analyzed data from 642 18–28 years olds from the Terneuzen Birth Cohort. Individual BMI SDS trajectories were fitted by a piecewise linear model. By multiple regression analyses relationships were assessed between subsequent conditional BMI SDS changes and components of the metabolic syndrome (MetS), skinfold thickness and hsCRP at young adulthood. Results were adjusted for gender and age, and other confounders. Gender was studied as an effect modifier. All BMI SDS changes throughout childhood were related to waist circumference and skinfold thickness. No other significant relationship was found before the age of 2 years, except between the BMI SDS change 0–1y and hsCRP. Fasting blood glucose was not predicted by any BMI SDS change. BMI SDS change 2–6y was strongly related to most outcome variables, especially to waist circumference (ß 0.47, SE 0.02), systolic and diastolic blood pressure (ß 0.20 SE 0.04 and ß 0.19 SE 0.03), and hsCRP (ß 0.16 SE 0.04). The BMI SDS change 10–18y was most strongly related to HDL cholesterol (ß -0.10, SE 0.03), and triglycerides (ß 0.21, SE 0.03). To a lesser degree, the BMI SDS change 6–10y was related to most outcome variables. BMI SDS changes 2–6y and 10–18y were significantly related to MetS: the OR was respectively 3.39 (95%CI 2.33–4.94) and 2.84 (95%CI 1.94–4.15). BMI SDS changes from 2y onwards were related to cardiometabolic risk at young adulthood, the age interval 2–6y being the most predictive. Monitoring and stabilizing the BMI SDS of children as young as 2–6y may not only reverse the progression towards adult overweight, but it may also safeguard cardiometabolic status.
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影响因子：
3.7
作者：
De Kroon ML;Renders CM;Van Wouwe JP;Van Buuren S;Hirasing RA
通讯作者：
Hirasing RA
影响因子：
4.9
作者：
Gonzalez, D. A.;Nazmi, A.;Victora, C. G.
通讯作者：
Victora, C. G.
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
37.8
作者：
Law, CM;Shiell, AW;de Swiet, M
通讯作者：
de Swiet, M
影响因子：
5
作者：
Boulat, O;Krieg, MA;Bachmann, C
通讯作者：
Bachmann, C