Growth from birth to adulthood and abdominal obesity in a Brazilian birth cohort.
Growth from birth to adulthood and abdominal obesity in a Brazilian birth cohort.
复制标题
DOI：
10.1038/ijo.2009.201
复制
发表时间：
2010-01
影响因子：
4.9
通讯作者：
Victora, C. G.
中科院分区：
文献类型：
--
作者：
Gonzalez, D. A.;Nazmi, A.;Victora, C. G.
儿童时期体重快速增加可能会增加患慢性成人疾病的风险。很少有研究探讨生命全程体重增加对腰围 (WC)、臀围 (HC) 或腰臀比 (WHR) 的影响。评估出生体重和从出生到 23 岁的体重增加对年轻人的腰围、腰围和腰臀比的影响。基于人口的出生队列研究始于 1982 年。2006 年对 856 名个体进行了样本检查。在调整混杂因素的情况下进行了条件生长分析。 WC和HC也相互调整。研究的所有年龄范围（出生体重、0-2、2-4、4-15、15-18/19 和 18/19-23 岁）的体重增加与男女的 WC 和 HC 呈正相关。这些影响在 4 至 15 岁范围内最强（两个周长 β=5.0 cm）。内脏脂肪组织的替代指标（根据 HC 调整的腰臀比和腰围）与女性 2 年后和男性 4 年后的体重增加相关。根据 WC 调整后的 HC 评估，皮下脂肪和肌肉组织与两性的出生体重和 0 至 2 岁时的体重增加相关，并且与男性 4 至 18 岁和女性 4 至 15 岁时的体重增加相关。子宫内和头 2 年内的体重增加对 HC 有长期影响，但 4 岁后的体重增加与 WC 密切相关。中等收入环境中，2 岁以下体重增加可能会降低与成人脂肪模式相关的心血管风险。
Rapid weight gain in childhood may increase the risk of chronic adult diseases. Few studies have examined the effects of lifecourse weight gain on waist circumference (WC), hip circumference (HC), or waist-to-hip ratio (WHR). To evaluate the effects of birthweight and weight gain from birth to age 23 years on WC, HC, and WHR in young adults. Population-based birth cohort study started in 1982. A sample of 856 individuals was examined in 2006. Conditional growth analyses were carried out with adjustment for confounders. WC and HC were also mutually adjusted. Weight gains during all age ranges studied (birthweight, 0–2, 2–4, 4–15, 15–18/19, and 18/19–23 years) were positively associated with WC and HC in both sexes. These effects were strongest from 4 to 15 years range (β=5.0 cm for both circumferences). Proxies for visceral adipose tissue (WHR and WC adjusted for HC) were associated with weight gain after 2 years in females and after 4 years in males. Subcutaneous adipose and muscular tissues, assessed by HC adjusted for WC, were associated with birthweight and weight gain from 0 to 2 years in both sexes, and again with weight gains from 4 to 18 years in males and 4 to 15 years in females. Weight gains in utero and in the first 2 years had long-term effects on HC, but weight gain after age 4 years was strongly associated with WC. Weight gains up to age 2 years may reduce cardiovascular risk associated with adult fat patterns in a middle-income setting.
登录
查看更多内容
影响因子：
7
作者：
Dunger, D. B.;Salgin, B.;Ong, K. K.
通讯作者：
Ong, K. K.
影响因子：
8.2
作者：
Byberg, L;McKeigue, PM;Lithell, HO
通讯作者：
Lithell, HO
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG
影响因子：
7.1
作者：
McCarthy, Anne;Hughes, Rachael;Ben-Shlomo, Yoav
通讯作者：
Ben-Shlomo, Yoav
影响因子：
4.9
作者：
Loos, RJF;Beunen, G;Vlietinck, R
通讯作者：
Vlietinck, R