Defining Post-COVID Symptoms (Post-Acute COVID, Long COVID, Persistent Post-COVID): An Integrative Classification.

Defining Post-COVID Symptoms (Post-Acute COVID, Long COVID, Persistent Post-COVID): An Integrative Classification.
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DOI:
10.3390/ijerph18052621
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发表时间:
2021-03-05
影响因子:
--
通讯作者:
Florencio LL
Florencio LL
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Fernández-de-Las-Peñas C;Palacios-Ceña D;Gómez-Mayordomo V;Cuadrado ML;Florencio LL

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2019冠状病毒病(COVID-19)的大流行引发了第二次大流行,即“长途运输者”,即,出现COVID后症状的个人。我们建议,为了确定COVID后症状的存在,症状应该在SARS-CoV-2感染诊断后出现;然而,这种情况存在一些问题,因为并非所有SARS-CoV-2感染者都接受这种诊断。基于COVID后症状的复发/缓解性质,提出了以下综合分类:潜在感染相关症状(长达4-5周),急性COVID后症状(从第5周至第12周),长期COVID后症状(从第12周至第24周)和持续COVID后症状(持续超过24周)。最重要的议题是建立时间参考点。该分类还整合了可能促进COVID后症状的诱发内在和外在因素以及住院数据。“长途运输者”表现出的影响多个系统的大量症状表明存在不同的潜在机制。
The pandemic of the coronavirus disease 2019 (COVID-19) has provoked a second pandemic, the “long-haulers”, i.e., individuals presenting with post-COVID symptoms. We propose that to determine the presence of post-COVID symptoms, symptoms should appear after the diagnosis of SARS-CoV-2 infection; however, this situation has some problems due to the fact that not all people infected by SARS-CoV-2 receive such diagnosis. Based on relapsing/remitting nature of post-COVID symptoms, the following integrative classification is proposed: potentially infection related-symptoms (up to 4–5 weeks), acute post-COVID symptoms (from week 5 to week 12), long post-COVID symptoms (from week 12 to week 24), and persistent post-COVID symptoms (lasting more than 24 weeks). The most important topic is to establish the time reference points. The classification also integrates predisposing intrinsic and extrinsic factors and hospitalization data which could promote post-COVID symptoms. The plethora of symptoms affecting multiple systems exhibited by “long-haulers” suggests the presence of different underlying mechanisms.
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