Maternal obesity and increased risk for autism and developmental delay among very preterm infants.
Maternal obesity and increased risk for autism and developmental delay among very preterm infants.
复制标题
DOI：
10.1038/jp.2014.80
复制
发表时间：
2014-09
影响因子：
2.9
通讯作者：
Rogers, C. E.
中科院分区：
文献类型：
--
作者：
Reynolds, L. C.;Inder, T. E.;Neil, J. J.;Pineda, R. G.;Rogers, C. E.
35%的育龄女性肥胖，并且有证据表明母亲肥胖可能会增加不良神经发育结果的风险。然而，关于早产儿童中肥胖与神经发育的研究有限。本研究旨在确定母亲肥胖与2岁极早产儿神经发育之间的关联。
孕周≤30周出生的母婴对子（n = 62）被纳入一家三级新生儿重症监护病房的前瞻性队列研究。根据孕前体重指数将母亲分为肥胖组和非肥胖组。婴儿在相当于足月时接受磁共振成像检查，并在2岁时进行发育测试。研究母亲肥胖与神经发育的关联。
母亲肥胖与自闭症筛查阳性相关（比值比 = 9.88，p = 0.002），且综合语言得分较低（β = -9.36，[置信区间 = -15.11，-3.61]，p = 0.002）。
在这组极早产儿中，母亲肥胖与2岁时不良神经发育结果相关。本研究需要重复验证，但可能支持对母亲肥胖的女性所生婴儿进行有针对性的监测。
Thirty-five percent of women of child-bearing age are obese, and there is evidence that maternal obesity may increase the risk for adverse neurodevelopmental outcome. However, research regarding obesity and neurodevelopment among children born preterm is limited. This study aimed to determine associations between maternal obesity and neurodevelopment in very preterm children at age 2 years. Maternal/infant dyads (n=62) born ≤30 weeks gestation were enrolled in a prospective cohort study at a level-III neonatal intensive care unit. Mothers were classified as obese or non-obese based on pre-pregnancy body mass index. Infants underwent magnetic resonance imaging at term equivalent and developmental testing at age 2. Maternal obesity was investigated for associations with neurodevelopment. Maternal obesity was associated with positive screen for autism (OR=9.88, p=0.002) and lower composite language scores (β=-9.36, [CI=-15.11, -3.61], p=0.002). Maternal obesity was associated with adverse neurodevelopmental outcome at age 2 in this cohort of very preterm children. This study requires replication, but may support targeted surveillance of infants born to women with maternal obesity.
登录
查看更多内容
DOI：
10.1001/archpediatrics.2010.20
发表时间：
2010-04-01
影响因子：
--
作者：
Anderson, Peter J.;De Luca, Cinzia R.;Doyle, Lex W.
通讯作者：
Doyle, Lex W.
影响因子：
8
作者：
Klinger, Gil;Levy, Itzhak;Reichman, Brian
通讯作者：
Reichman, Brian
影响因子：
8
作者：
Cheong, Jeanie L. Y.;Hunt, Rod W.;Doyle, Lex W.
通讯作者：
Doyle, Lex W.
影响因子：
8
作者：
Helderman, Jennifer B.;O'Shea, Thomas M.;Leviton, Alan
通讯作者：
Leviton, Alan
DOI：
10.1523/jneurosci.4682-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
通讯作者：
Van Essen D