Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.
Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release.
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DOI：
10.1021/nn901181c
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发表时间：
2010-02-23
期刊：
影响因子：
17.1
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
You J;Zhang G;Li C
我们报告了双功能中空金纳米球（HAuNS，直径约40 nm），能够介导光热消融癌细胞和药物释放后，近红外（NIR）光照射。高达63重量%的DOX（约1.7 μg DOX/μg Au）可以负载到聚乙二醇（PEG）涂覆的HAuNS上，因为DOX涂覆到HAuNS的外表面和内表面两者上。近红外激光照射诱导光热转换，从而触发DOX从DOX负载的HAuNS中快速释放。DOX的释放也是pH依赖性的，在较低的pH下，在水溶液中释放更多的DOX。当用装载DOX的HAuNS孵育的MDA-MB-231细胞用NIR光照射时，观察到显著更大的细胞杀伤，这归因于HAuNS介导的光热消融和释放的游离DOX的细胞毒性。
We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.
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影响因子：
4.9
作者：
Ajima, Kumiko;Yudasaka, Masako;Ijima, Sumio
通讯作者：
Ijima, Sumio
影响因子：
15
作者：
Kim CK;Ghosh P;Pagliuca C;Zhu ZJ;Menichetti S;Rotello VM
通讯作者：
Rotello VM
DOI：
10.1073/pnas.1132025100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Fan, CH;Wang, S;Heeger, AJ
通讯作者：
Heeger, AJ
影响因子：
4.3
作者：
Dhar, Sheetal;Reddy, E. Maheswara;Prasad, B. L. V.
通讯作者：
Prasad, B. L. V.
影响因子：
5.7
作者：
Melancon, Marites P.;Lu, Wei;Li, Chun
通讯作者：
Li, Chun