The Dynamic Selection Hypothesis: A Proposed Function for Cerebellar Sagittal Zones
The Dynamic Selection Hypothesis: A Proposed Function for Cerebellar Sagittal Zones
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动态选择假说：小脑矢状区的拟议函数
DOI：
10.1007/978-1-4612-2840-0_14
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发表时间：
1992
影响因子：
2.5
通讯作者：
T. M. Kelly
中科院分区：
文献类型：
--
作者：
J. Bloedel;T. M. Kelly
本章回顾了我们最近对攀爬纤维对单个浦肯野细胞的异质突触作用的研究，并提出了一个关于小脑矢状区功能基础的新假设，即“动态选择”假设。这一假设是通过对我们的研究结果以及来自其他实验室的研究结果的讨论而提出的，在两种关于攀爬纤维功能的理论的背景下：一种提出这些传入神经在建立运动学习所需的小脑皮层中的印迹中发挥着重要作用，另一种则认为攀爬纤维对于小脑在运动执行过程中执行的实时操作最为关键。我们的实验通过证明攀爬纤维在被动范例中以及在扰动运动过程中多个矢状组织的浦肯野细胞中对简单尖峰反应的特定短期作用来支持后一种观点。其他研究小脑消融对兔子经典条件性瞬膜/眨眼反应的影响证实了我们之前的观点，即小脑对于目前用作运动学习模型的这种条件性行为既不充分也没有必要。
This chapter reviews our recent studies of the climbing fiber’s heterosynaptic action on individual Purkinje cells and presents a new hypothesis, the “dynamic selection” hypothesis, regarding the functional basis for the sagittal zones of the cerebellum. This hypothesis is developed through a discussion of our findings as well as those from other laboratories in the context of two theories of climbing fiber function: one proposing that these afferents perform a major role in establishing en-grams in the cerebellar cortex required for motor learning and the other arguing that climbing fibers are most critical for real-time operations performed by the cerebellum during motor execution. Our experiments support the latter view by demonstrating a specific short-term action of climbing fibers on simple spike responses in passive paradigms as well as in multiple, sagittally organized Purkinje cells during perturbed locomotion. Other studies examining the effect of cerebellar ablation on the classically conditioned nictitating membrane/eyeblink response in rabbits substantiate our previously held contention that the cerebellum is neither sufficient nor necessary for this type of conditioned behavior currently being used as models for motor learning.
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影响因子：
2.5
作者：
EBNER, TJ;YU, QX;BLOEDEL, JR
通讯作者：
BLOEDEL, JR
影响因子：
2.5
作者：
T. Ebner;J. Bloedel
通讯作者：
T. Ebner;J. Bloedel
影响因子：
5.5
作者：
LLINAS, R;SUGIMORI, M
通讯作者：
SUGIMORI, M
影响因子：
56.9
作者：
David W. Tank;M. Sugimori;John A. Connor;R. R. Llinás-R.
通讯作者：
David W. Tank;M. Sugimori;John A. Connor;R. R. Llinás-R.