Depressive symptoms, lifestyle structure, and ART adherence among HIV-infected individuals: a longitudinal mediation analysis.
Depressive symptoms, lifestyle structure, and ART adherence among HIV-infected individuals: a longitudinal mediation analysis.
复制标题
DOI：
10.1007/s10461-014-0802-3
复制
发表时间：
2015-01
影响因子：
4.4
通讯作者：
Wagner, Glenn J.
中科院分区：
文献类型：
--
作者：
Magidson, Jessica F.;Blashill, Aaron J.;Safren, Steven A.;Wagner, Glenn J.
Despite the well-documented relationship between depression and antiretroviral therapy (ART) non-adherence, few studies have identified explanatory pathways through which depression affects adherence. The current study tested lifestyle structure—the degree of organization and routinization of daily activities—as a mediator of this relationship, given previous evidence of lifestyle structure being associated with both depression and ART nonadherence. HIV-infected individuals starting or re-starting ART in the California Collaborative Treatment Group 578 study (n = 199) were assessed over 48 weeks. Adherence was measured using electronic monitoring caps to determine dose timing and doses taken, and viral load was assessed. The mediating role of lifestyle structure was tested using generalized linear mixed-effects modeling and bootstrapping. Lifestyle significantly mediated the relationship between depression and both measures of ART adherence behavior. Interventions that minimize disruptions to lifestyle structure and link adherence to daily activities may be useful for individuals with depression and ART nonadherence.
登录
查看更多内容
DOI：
10.1097/00042560-200205010-00014
发表时间：
2002-05-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
de Olalla, PG;Knobel, H;Caylà, JA
通讯作者：
Caylà, JA
影响因子：
2.9
作者：
Daughters SB;Magidson JF;Schuster RM;Safren SA
通讯作者：
Safren SA
影响因子：
2.9
作者：
Kobin, Allison Beth;Sheth, Neha Umesh
通讯作者：
Sheth, Neha Umesh
影响因子：
3.7
作者：
Carvalho, John P.;Gawrysiak, Michael J.;Hopko, Derek R.
通讯作者：
Hopko, Derek R.
DOI：
10.1097/qai.0b013e3181b720e7
发表时间：
2010-02-01
影响因子：
3.6
作者：
Kacanek, Deborah;Jacobson, Denise L.;Wilson, Ira B.
通讯作者：
Wilson, Ira B.