From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention.
From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention.
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DOI：
10.1111/prd.12127
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发表时间：
2016-10
影响因子：
18.6
通讯作者：
Helms JA
中科院分区：
文献类型：
--
作者：
Huang L;Salmon B;Yin X;Helms JA
随着时间的推移，我们的身体开始磨损：视力衰退，皮肤失去弹性，牙齿和骨骼变得更加脆弱，伤口愈合更慢。这些衰老的普遍特征可以追溯到我们的干细胞。衰老对干细胞有着深远的影响：随着时间的推移，DNA突变会自然积累，我们的身体已经进化出高度专业化的机制来清除这些受损的细胞。虽然明显有益，但这种修复机制也减少了可用干细胞的数量，这反过来又对组织的稳态和我们的愈合速度产生了巨大的影响。简单地说：干细胞减少意味着组织功能下降，愈合速度减慢。尽管这种情况看似棘手，但过去十年的研究表明，衰老的一些影响是可逆的。获得诺贝尔奖的研究表明，衰老的细胞可以再次变年轻，从这些实验中吸取的经验教训现在正在转化为人类疗法。世界各地的科学家和临床医生正在识别和表征激活干细胞的方法，以重振身体的自然再生过程。如果这项牙齿再生医学的研究成功，最终的结果将是组织的体内平衡和愈合回到我们年轻时所欣赏的水平。
With the march of time our bodies start to wear out: eyesight fades, skin loses its elasticity, teeth and bones become more brittle, and injuries heal more slowly. These universal features of aging can be traced back to our stem cells. Aging has a profound effect on stem cells: DNA mutations naturally accumulate over time and our bodies have evolved highly specialized mechanisms to remove these damaged cells. While obviously beneficial, this repair mechanism also reduces the pool of available stem cells and this, in turn, has a dramatic effect on tissue homeostasis, and our rate of healing. Simply put: fewer stem cells means a decline in tissue function, and slower healing. Despite this seemingly intractable situation, research over the past decade now demonstrates that some of the effects of aging are reversible. Nobel prize-winning research demonstrates that old cells can become young again and lessons learned from these experiments-in-a-dish are now being translated into human therapies. Scientists and clinicians around the world are identifying and characterizing methods to activate stem cells to reinvigorate the body’s natural regenerative process. If this research in dental regenerative medicine pans out, the end result will be tissue homeostasis and healing back to the levels we appreciated when we were young.
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影响因子：
3.5
作者：
Coura, G. S.;Garcez, R. C.;Trentin, A. G.
通讯作者：
Trentin, A. G.
影响因子：
4.1
作者：
Cawthorn WP;Bree AJ;Yao Y;Du B;Hemati N;Martinez-Santibañez G;MacDougald OA
通讯作者：
MacDougald OA
影响因子：
2.2
作者：
Alessandro, Scardina Giuseppe;Antonino, Cacioppo;Messina, Pietro
通讯作者：
Messina, Pietro
影响因子：
5.2
作者：
Collins, Charlotte A.;Zammit, Peter S.;Partridge, Terence A.
通讯作者：
Partridge, Terence A.
DOI：
10.1002/ar.a.20066
发表时间：
2004-08-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Bloebaum, RD;Kopp, DV
通讯作者：
Kopp, DV