Chronic electrical stimulation of the contralesional lateral cerebellar nucleus enhances recovery of motor function after cerebral ischemia in rats.
Chronic electrical stimulation of the contralesional lateral cerebellar nucleus enhances recovery of motor function after cerebral ischemia in rats.
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DOI：
10.1016/j.brainres.2009.05.007
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发表时间：
2009-07-14
期刊：
影响因子：
2.9
通讯作者：
Rezai A
中科院分区：
文献类型：
--
作者：
Machado AG;Baker KB;Schuster D;Butler RS;Rezai A
需要新的神经康复策略来改善中风后的运动预后。基于齿状丘脑皮质通路对运动皮质以及皮质前部和后部区域的失突触兴奋性投射，我们假设慢性电刺激对侧齿状核（小脑外侧）输出可以通过增强皮层周围兴奋性来增强缺血后的运动恢复。75只Wistar大鼠进行蒙托亚楼梯任务预训练，随后进行三血管闭塞模型左脑缺血。所有幸存者都接受了立体定向右外侧小脑核（LCN）双极电极植入。然后将大鼠随机分为4组：LCN刺激10pps、20pps、50pps或假刺激，持续6周。在刺激期的最后四周，对蒙托亚任务的表现进行了重新评估。右（对侧）侧，假手术、10pps、20pps和50pps刺激组的运动表现分别为2.5±2.7；2.1±2.5；6.0±3.9粒（p<0.01）和4.5±3.5粒。假手术组和刺激组左（同侧）侧运动表现无差异，变化范围为15.9±6.7至17.2±2.1粒。我们得出结论，对小脑外侧核进行20pps的慢性电刺激，而不是10pps或50pps，可以改善缺血性中风大鼠的运动恢复。这种效应可能是通过牙状丘脑皮质通路的慢性激活而增加的病灶周围皮层兴奋性所介导的。
Novel neurorehabilitative strategies are needed to improve motor outcomes following stroke. Based on the disynaptic excitatory projections of the dentatothalamocortical pathway to the motor cortex as well as anterior and posterior cortical areas, we hypothesize that chronic electrical stimulation of the contralesional dentate (lateral cerebellar) nucleus output can enhance motor recovery after ischemia via augmentation of perilesional cortical excitability. Seventy five Wistar rats were pre-trained in the Montoya staircase task and subsequently suffered left cerebral ischemia with the 3-vessel occlusion model. All survivors underwent stereotactic right lateral cerebellar nucleus (LCN) implantation of bipolar electrodes. Rats were then randomized to 4 groups: LCN stimulation at 10 pps, 20 pps, 50 pps or sham stimulation, which was delivered for a period of six weeks. Performance on the Montoya task was re-assessed over the last four weeks of the stimulation period. On the right (contralesional) side, motor performance of the groups undergoing sham, 10 pps, 20 pps and 50 pps stimulation was, respectively, 2.5± 2.7; 2.1 ± 2.5; 6.0 ± 3.9 (p<0.01) and 4.5 ± 3.5 pellets. There was no difference on the left (ipsilesional) side motor performance among the sham or stimulation groups, varying from 15.9 ± 6.7 to 17.2 ± 2.1 pellets. We conclude that contralesional chronic electrical stimulation of the lateral cerebellar nucleus at 20 pps but not at 10 or 50 pps improves motor recovery in rats following ischemic strokes. This effect is likely to be mediated by increased perilesional cortical excitability via chronic activation of the dentatothalamocortical pathway.
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DOI：
10.1016/s1052-3057(03)00042-9
发表时间：
2003-05-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Kelly-Hayes, Margaret;Beiser, Alexa;Wolf, Philip A
通讯作者：
Wolf, Philip A
影响因子：
--
作者：
ASANUMA, C;THACH, WT;JONES, EG
通讯作者：
JONES, EG
影响因子：
4.3
作者：
Chen, CL;Tang, FT;Wong, MK
通讯作者：
Wong, MK
DOI：
10.1111/j.1749-6632.2002.tb07575.x
发表时间：
2002-01-01
期刊：
CREBELLUM: RECENT DEVELOPMENTS IN CEREBELLAR RESEARCH
影响因子：
--
作者：
Dum, RP;Li, C;Strick, PL
通讯作者：
Strick, PL
影响因子：
8.3
作者：
DeBow, SB;Davies, MLA;Colbourne, F
通讯作者：
Colbourne, F