Gastric cancer stem cells: a novel therapeutic target.
Gastric cancer stem cells: a novel therapeutic target.
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DOI：
10.1016/j.canlet.2013.03.035
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发表时间：
2013-09-10
期刊：
影响因子：
9.7
通讯作者：
Singh, Shree Ram
中科院分区：
文献类型：
--
作者：
Singh, Shree Ram
胃癌仍然是全球癌症死亡的主要原因之一。在小鼠和人的胃中都发现了多能性胃干细胞，它们在胃粘膜的自我更新和稳态中发挥着重要作用。有几个已知的环境和遗传因素可促进胃癌。近年来，大量体外和体内研究提示胃癌可能起源于正常干细胞或骨髓源性间充质细胞，胃癌肿瘤中含有肿瘤干细胞。肿瘤干细胞被认为与正常生态位具有共同的微环境，在胃癌和肿瘤生长中发挥重要作用。这篇综述简要介绍了胃癌干细胞研究的最新进展。通过研究胃粘膜中的癌症干细胞所获得的知识将支持新的胃癌治疗策略的发展。
Gastric cancer remains one of the leading causes of global cancer mortality. Multipotent gastric stem cells have been identified in both mouse and human stomachs, and they play an essential role in the self-renewal and homeostasis of gastric mucosa. There are several environmental and genetic factors known to promote gastric cancer. In recent years, numerous in vitro and in vivo studies suggest that gastric cancer may originate from normal stem cells or bone marrow–derived mesenchymal cells, and that gastric tumors contain cancer stem cells. Cancer stem cells are believed to share a common microenvironment with normal niche, which play an important role in gastric cancer and tumor growth. This mini-review presents a brief overview of the recent developments in gastric cancer stem cell research. The knowledge gained by studying cancer stem cells in gastric mucosa will support the development of novel therapeutic strategies for gastric cancer.
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