Adiposity has unique influence on the renin-aldosterone axis and blood pressure in black children.
Adiposity has unique influence on the renin-aldosterone axis and blood pressure in black children.
复制标题
肥胖对黑人儿童的肾素-醛固酮轴和血压具有独特的影响。
DOI：
10.1016/j.jpeds.2013.06.082
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Tu,Wanzhu
中科院分区：
文献类型：
--
作者：
Yu,Zhangsheng;Eckert,GeorgeJ;Liu,Hai;Pratt,JHoward;Tu,Wanzhu
目的比较研究肥胖对黑人和白人儿童血浆肾素活性（PRA）、血浆醛固酮浓度（PAC）及醛固酮-肾素比值（ARR）的影响。研究设计我们前瞻性地评估了248名黑人和345名白人儿童和青少年。采用一种新的分析技术来评估年龄和体重指数（BMI）对PRA、PAC和ARR的同时影响。估计效果用彩色等高线图表示。结果与白人相比，黑人的PRA （2.76 vs 3.36 ng/mL/h， P< 0.001）和PAC （9.01 vs 14.59 ng/dL， P< 0.001）较低。在黑人中，BMI与PRA呈负相关（P= .001），与血浆容量更大的相关性一致；在白人中，BMI与PAC呈正相关（P= 0.005）；我们没有发现BMI-PRA关联。BMI对ARR的影响在两个种族中方向相似，但在黑人中更为明显。低PRA （P< 0.01）、高PAC （P= 0.015）和高ARR （P= 0.49）的黑人平均收缩压更高。结论肥胖增加与黑人PRA抑制和白人PAC增加有关。黑人肥胖与肾素醛固酮轴之间的独特关系表明，可能存在以体积扩张为特征的人群特异性机制，这反过来又可能增强肥胖对黑人儿童和青少年血压的影响。
ObjectiveTo comparatively examine the effects of adiposity on the levels of plasma renin activity (PRA), plasma aldosterone concentration (PAC), and aldosterone-renin ratio (ARR) in young black and white children.Study designWe prospectively assessed 248 black and 345 white children and adolescents. A novel analytical technique was used to assess the concurrent influences of age and body mass index (BMI) on PRA, PAC, and ARR. The estimated effects were depicted by colored contour plots.ResultsIn contrast to whites, blacks had lower PRA (2.76 vs 3.36 ng/mL/h;P< .001) and lower PAC (9.01 vs 14.59 ng/dL;P< .001). In blacks, BMI was negatively associated with PRA (P= .001), consistent with an association with a more expanded plasma volume; there was no association with PAC. In whites, BMI was positively associated with PAC (P= .005); we did not detect a BMI-PRA association. The effects of BMI on ARR were directionally similar in the two race groups but more pronounced in blacks. Mean systolic blood pressure was greater in blacks with lower PRA (P< .01), higher PAC (P= .015), and higher ARR (P= .49).ConclusionsAn increase in adiposity was associated with a suppressed PRA in blacks and an increase in PAC in whites. The unique relationship between adiposity and renin-aldosterone axis in blacks suggests the possible existence of a population-specific mechanism characterized by volume expansion, which could in turn enhance the influences of adiposity on blood pressure in black children and adolescents.
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DOI：
--
发表时间：
1968
期刊：
影响因子：
--
作者：
A. Fasola;B. Martz;O. M. Helmer
通讯作者：
O. M. Helmer
影响因子：
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作者：
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通讯作者：
Allison, DB
DOI：
10.1002/j.1550-8528.1999.tb00418.x
发表时间：
1999-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Goodfriend, TL;Kelley, DE;Winters, SJ
通讯作者：
Winters, SJ
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影响因子：
3.2
作者：
Tu,Wanzhu;Eckert,GeorgeJ;Pratt,JHoward;JanDanser,AH
通讯作者：
JanDanser,AH
影响因子：
3.2
作者：
Kathiresan, S;Larson, MG;Vasan, RS
通讯作者：
Vasan, RS