Retinal Physiology and Circulation: Effect of Diabetes.
Retinal Physiology and Circulation: Effect of Diabetes.
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DOI：
10.1002/cphy.c190021
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发表时间：
2020-07-08
影响因子：
5.8
通讯作者：
Harris, Norman R.
中科院分区：
文献类型：
--
作者：
Wright, William S.;Eshaq, Randa S.;Lee, Minsup;Kaur, Gaganpreet;Harris, Norman R.
在这篇综述中，我们提出了一个讨论糖尿病及其并发症，包括大血管和微血管的影响，后者的后果视网膜。我们将讨论视网膜的解剖学和生理学，包括代谢和氧合机制的方面，后者通过视网膜和脉络膜血液循环的组合来完成。这两种血管都在糖尿病中改变，视网膜循环密切参与糖尿病视网膜病变的病理学。糖尿病视网膜病变的后期阶段涉及控制不良的血管生成，这是非常令人担忧的，但在我们的讨论中，我们将更多地关注在疾病进展早期发生的视网膜循环中的几种改变，包括血流减少和可能的灌注重新分布，这可能会使视网膜的某些区域缺血和缺氧。最后，我们在这篇综述中包括了一个最近的研究领域，即糖尿病视网膜血管系统，即内皮细胞表面层的改变，通常在维持生理功能方面起着至关重要的作用。
In this review, we present a discussion of diabetes and its complications, including the macrovascular and microvascular effects, with the latter of consequence to the retina. We will discuss the anatomy and physiology of the retina, including aspects of metabolism and mechanisms of oxygenation, with the latter accomplished via a combination of the retinal and choroidal blood circulations. Both of these vasculatures are altered in diabetes, with the retinal circulation intimately involved in the pathology of diabetic retinopathy. The later stages of diabetic retinopathy involve poorly controlled angiogenesis that is of great concern, but in our discussion, we will focus more on several alterations in the retinal circulation occurring earlier in the progression of disease, including reductions in blood flow and a possible redistribution of perfusion that may leave some areas of the retina ischemic and hypoxic. Finally, we include in this review a more recent area of investigation regarding the diabetic retinal vasculature, that is, the alterations to the endothelial surface layer that normally plays a vital role in maintaining physiological functions.
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DOI：
10.1111/j.1748-1716.1970.tb04765.x
发表时间：
1970-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ALM, A;BILL, A
通讯作者：
BILL, A
影响因子：
7.3
作者：
Abdouh, M;Khanjari, A;Hasséssian, HM
通讯作者：
Hasséssian, HM
影响因子：
3.4
作者：
ALM, A;BILL, A
通讯作者：
BILL, A
影响因子：
7.8
作者：
Albelda, S M;Muller, W A;Buck, C A;Newman, P J
通讯作者：
Newman, P J
影响因子：
5.4
作者：
Aird, William C.
通讯作者：
Aird, William C.