Theory of mind deficits partly mediate impaired social decision-making in schizophrenia
Theory of mind deficits partly mediate impaired social decision-making in schizophrenia
复制标题
心理理论缺陷在一定程度上介导了精神分裂症患者的社会决策受损
DOI：
10.1186/s12888-017-1313-3
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发表时间：
2017-05
期刊：
影响因子：
4.4
通讯作者：
Zhou Yuan
中科院分区：
文献类型：
--
作者：
Yang Liuqing;Li Peifu;Mao Haiying;Wang Huiling;Shu Chang;Bliksted Vibeke;Zhou Yuan
研究背景利用博弈论的范式，研究者报道了精神分裂症患者在社会环境中的异常决策。然而，人们对这种损害的基础知之甚少。本研究旨在测试是否心理理论（ToM）的缺陷和/或神经认知功能障碍介导受损的社会决策在patients with schizophrenia.MethodsWe比较了35例精神分裂症患者38个匹配的健康对照组方面的社会决策使用迷你最后通牒游戏（迷你UG），从博弈论的一个范例。此外，我们评估心理理论使用的心理理论图片故事任务，精神状态归因任务，并评估神经认知使用简要评估精神分裂症的认知。中介分析进行data.ResultsIn对比健康对照的行为模式在迷你UG中，精神分裂症患者显着接受更多的不利提供和拒绝更有利的报价，并表现出降低敏感性的公平相关的背景变化的迷你UG。患者还发现ToM和神经认知受损。中介分析表明，心理理论，但不是神经认知部分介导的群体差异的不利和有利的提供在迷你UG。结论精神分裂症患者表现出受损的社会决策。这种损害可以部分解释为他们的心理理论缺陷，而不是神经认知缺陷。然而，调解受损的社会决策的ToM赤字的确切性质需要在未来确定。
BackgroundUsing paradigms from game theory, researchers have reported abnormal decision-making in social context in patients with schizophrenia. However, less is known about the underpinnings of the impairment. This study aimed to test whether theory of mind (ToM) deficits and/or neurocognitive dysfunctions mediate impaired social decision-making in patients with schizophrenia.MethodsWe compared thirty-five patients with schizophrenia to thirty-eight matched healthy controls with regard to social decision-making using the mini Ultimatum Game (mini UG), a paradigm from game theory. Additionally, we assessed ToM using the Theory of Mind Picture Stories Task, a mental state attribution task, and assessed neurocognition using the Brief Assessment of Cognition in Schizophrenia. Mediation analyses were performed on the data.ResultsIn contrast to the behavioral pattern of healthy controls in the mini UG, the patients with schizophrenia significantly accepted more disadvantageous offers and rejected more advantageous offers, and showed reduced sensitivity to the fairness-related context changes in the mini UG. Impaired ToM and neurocognition were also found in the patients. Mediation analyses indicated that ToM but not neurocognition partially mediated the group differences on the disadvantageous and advantageous offers in the mini UG.ConclusionsPatients with schizophrenia exhibited impaired social decision-making. This impairment can be partly explained by their ToM deficits rather than neurocognitive deficits. However, the exact nature of the ToM deficits that mediate impaired social decision-making needs to be identified in future.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
3.4
作者：
M. Bosia;R. Riccaboni;S. Poletti
通讯作者：
M. Bosia;R. Riccaboni;S. Poletti
影响因子：
1.7
作者：
Langdon, R;Michie, P T;Coltheart, M
通讯作者：
Coltheart, M
影响因子：
2.9
作者：
Radke S;Brazil IA;Scheper I;Bulten BH;de Bruijn ER
通讯作者：
de Bruijn ER
影响因子：
4.2
作者：
Guroglu, Berna;van den Bos, Wouter;Crone, Eveline A.
通讯作者：
Crone, Eveline A.