Devo-Aging: Intersections Between Development and Aging.
Devo-Aging: Intersections Between Development and Aging.
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DOI：
10.1007/s11357-023-00809-2
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发表时间：
2023-08
期刊：
影响因子：
5.6
通讯作者：
Silva-Garcia, Carlos Giovanni
中科院分区：
文献类型：
--
作者：
Silva-Garcia, Carlos Giovanni
发育生物学中有两个基本问题。一个受精卵细胞是如何形成一个完整的身体的？这个身体后来是如何产生后代的？这些胚胎和胚胎后发育的同步确保了生命从一代到下一代的连续性。人们已经做了大量的工作来揭示这些过程背后的分子机制，但最近，现代发育生物学已经扩展到更广泛的背景下研究发育，包括再生、环境、疾病甚至衰老。然而，我们刚刚开始了解控制发育的机制如何也调节衰老。本文讨论了发育过程中涉及的信号通路的例子，以阐明它们的调节如何影响健康寿命和寿命。因此，更好地了解发育信号通路强调了将其作为衰老和年龄相关疾病的创新生物标志物和靶点的可能性。
There are two fundamental questions in developmental biology. How does a single fertilized cell give rise to a whole body? and how does this body later produce progeny? Synchronization of these embryonic and postembryonic developments ensures continuity of life from one generation to the next. An enormous amount of work has been done to unravel the molecular mechanisms behind these processes, but more recently, modern developmental biology has been expanded to study development in wider contexts, including regeneration, environment, disease, and even aging. However, we have just started to understand how the mechanisms that govern development also regulate aging. This review discusses examples of signaling pathways involved in development to elucidate how their regulation influences healthspan and lifespan. Therefore, a better knowledge of developmental signaling pathways stresses the possibility of using them as innovative biomarkers and targets for aging and age-related diseases.
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