Endothelium-dependent relaxation of hypertensive resistance arteries is not impaired under all conditions.
Endothelium-dependent relaxation of hypertensive resistance arteries is not impaired under all conditions.
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抗高血压动脉的内皮依赖性松弛在所有情况下都不会受到损害。
DOI：
10.1161/01.res.72.2.290
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发表时间：
1993
影响因子：
20.1
通讯作者：
Bukoski,RD
中科院分区：
文献类型：
--
作者：
Li,J;Bukoski,RD
本文研究了自发性高血压大鼠（SHR）和正常血压大鼠（WKY）肠系膜阻力动脉的内皮依赖性舒张功能。乙酰胆碱诱导的SHR血管舒张与10 μ M去甲肾上腺素预收缩内皮依赖性和衰减相比，WKY血管。吲哚美辛抑制环氧合酶可使SHR血管的受损反应恢复正常。用NG-硝基-L-精氨酸甲酯（L-NAME）阻断一氧化氮合成酶或用亚甲蓝抑制鸟苷酸环化酶可减弱乙酰胆碱诱导的去甲肾上腺素收缩SHR血管的舒张作用，但对WKY血管无影响。当血管预收缩与30 nM精氨酸加压素，乙酰胆碱诱导类似程度的放松在两个菌株。当使用赖氨酸加压素诱导张力时，检测到类似的反应。吲哚美辛对SHR和WKY血管的舒张反应没有影响。L-NAME和亚甲蓝部分抑制乙酰胆碱诱导的血管加压素收缩血管的舒张。在基线时添加乙酰胆碱不会诱导来自任一品系的血管收缩。可以得出结论，SHR阻力动脉的内皮依赖性舒张在所有情况下都没有受损。乙酰胆碱诱导的舒张可能会被抑制在SHR阻力动脉时，去甲肾上腺素是用来诱导收缩作为结果的儿茶酚胺诱导的生产的内皮源性收缩因子。加压素，另一方面，不引起这种收缩因子的生产，并可能通过对内皮细胞或血管平滑肌细胞的作用增强乙酰胆碱在两种品系的阻力动脉中的血管舒张作用。
Endothelium-dependent relaxation of mesenteric resistance arteries of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats was studied. Acetylcholine-induced relaxation of SHR vessels precontracted with 10 microM norepinephrine was endothelium dependent and attenuated compared with WKY vessels. The impaired response of SHR vessels was normalized by inhibition of cyclooxygenase with indomethacin. Blockade of nitric oxide synthetase with NG-nitro L-arginine methyl ester (L-NAME) or inhibition of guanylate cyclase with methylene blue attenuated acetylcholine-induced relaxation of norepinephrine-contracted SHR vessels but had no effect on WKY vessels. When vessels were precontracted with 30 nM arginine vasopressin, acetylcholine induced similar degrees of relaxation in both strains. A similar response was detected when lysine vasopressin was used to induce tone. Indomethacin had no effect on relaxation responses of SHR and WKY vessels precontracted with either form of vasopressin. L-NAME and methylene blue partially inhibited acetylcholine-induced relaxation of vasopressin-contracted vessels from both strains. Acetylcholine added at baseline did not induce contraction of vessels from either strain. It is concluded that endothelium-dependent relaxation of SHR resistance arteries is not impaired under all circumstances. Acetylcholine-induced relaxation may be suppressed in SHR resistance arteries when norepinephrine is used to induce contraction as a result of catecholamine-induced production of an endothelium-derived contracting factor. Vasopressin, on the other hand, does not elicit production of this contracting factor and may enhance the vasorelaxant action of acetylcholine in resistance arteries of both strains via actions on endothelial or vascular smooth muscle cells.
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影响因子：
4.9
作者：
CORDELLINI, S;CARVALHO, MHC;NIGRO, D
通讯作者：
NIGRO, D
注射 1,25-(OH)2 维生素 D3 可增强阻力动脉收缩特性。
DOI：
10.1161/01.hyp.16.5.523
发表时间：
1990
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Bukoski,RD;Wang,DB;Wagman,DW
通讯作者：
Wagman,DW
影响因子：
4
作者：
RUBANYI, GM
通讯作者：
RUBANYI, GM
影响因子：
8.3
作者：
KATO, T;IWAMA, Y;SATAKE, T
通讯作者：
SATAKE, T
1,25 (OH)2 维生素 D3 可减轻与培养基中孵育相关的阻力动脉收缩功能的丧失。
DOI：
10.1016/0006-291x(91)90477-o
发表时间：
1991
影响因子：
3.1
作者：
Xue,H;McCarron,DA;Bukoski,RD
通讯作者：
Bukoski,RD