1,25 (OH)2 vitamin D3 attenuates the loss of resistance artery contractile function associated with incubation in culture media.

1,25 (OH)2 vitamin D3 attenuates the loss of resistance artery contractile function associated with incubation in culture media.
复制标题

1,25 (OH)2 维生素 D3 可减轻与培养基中孵育相关的阻力动脉收缩功能的丧失。

DOI:
10.1016/0006-291x(91)90477-o
复制
发表时间:
1991
影响因子:
3.1
通讯作者:
Bukoski,RD
Bukoski,RD
中科院分区:
生物学4区
文献类型:
--
作者:
Xue,H;McCarron,DA;Bukoski,RD

文献摘要

参考文献

被引文献

相似文献

大鼠肠系膜阻力动脉在分离后即刻或在含有胰岛素、转铁蛋白和抗生素的改良的Eagle‘s/Ham’s F-12(1:1)培养液中孵育48小时后,观察其收缩特性。在培养液中孵育抑制了主动应激产生能力,增加了对去甲肾上腺素的敏感性,并消融了内皮依赖性的松弛。应激产生的减少是由于细胞内可释放的钙离子池的丧失;敏感性的增强与神经元胺泵功能的降低有关。在培养液中加入300pg/ml1,25(OH)2维生素D3,可几乎完全防止应激产生能力的丧失,并部分保留内皮功能。结论:1,25(OH)2维生素D3可部分抑制培养条件引起的血管肌细胞表型改变。
Contractile properties of rat mesenteric resistance arteries were studied immediately after isolation or after 48-hr incubation in culture medium [Dulbecco's modified Eagle's/Ham's F-12 (1:1) with insulin, transferrin and antibiotics]. Incubation in culture medium depressed active stress generating capacity, increased sensitivity to norepinephrine and ablated endothelium-dependent relaxation. The decrease in stress generation results from the loss of a releasable pool of intracellular Ca2+; the enhanced sensitivity is associated with decreased neuronal amine pump function. Addition of 300 pg/ml 1,25 (OH)2vitamin D3to the culture medium afforded nearly complete protection against the loss of stress generating capacity and partially preserved endothelial function. It is concluded that 1,25 (OH)2vitamin D3partially prevents phenotypic modulation of the vascular myocyte induced by culture conditions.
注射 1,25-(OH)2 维生素 D3 可增强阻力动脉收缩特性。
DOI: 10.1161/01.hyp.16.5.523
发表时间: 1990
期刊: Hypertension (Dallas, Tex. : 1979)
影响因子: --
作者:
Bukoski,RD;Wang,DB;Wagman,DW
通讯作者: Wagman,DW
1,25(OH)2 维生素 D3 和离子化 Ca2 对自发性高血压大鼠和 Wistar京都正常血压大鼠主动脉肌细胞原代培养物吸收 45Ca 的影响。
DOI: 10.1016/0006-291x(87)90795-9
发表时间: 1987
影响因子: 3.1
作者:
R. Bukoski;H. Xue;D. McCarron
通讯作者: D. McCarron
DOI: 10.1016/s0006-291x(88)80439-x
发表时间: 1988-05-16
影响因子: 3.1
作者:
INOUE, T;KAWASHIMA, H
通讯作者: KAWASHIMA, H
胰岛素对血栓素 A2 诱导的猪冠状动脉血管收缩的影响。
DOI: 10.1161/01.cir.81.5.1654
发表时间: 1990
期刊: Circulation
影响因子: 37.8
作者:
Atsuko Yanagisawa;Hideki Ito;Tsuneaki Sugimoto
通讯作者: Tsuneaki Sugimoto
胰岛素对兔股动脉和静脉去甲肾上腺素和血管紧张素II血管收缩反应的影响
DOI: --
发表时间: 1988
期刊: Diabetes
影响因子: 7.7
作者:
Shinji Yagi;S. Takata;Hiroaki Kiyokawa;M. Yamamoto;Y. Noto;T. Ikeda;N. Hattori
通讯作者: N. Hattori