1,25 (OH)2 vitamin D3 attenuates the loss of resistance artery contractile function associated with incubation in culture media.
1,25 (OH)2 vitamin D3 attenuates the loss of resistance artery contractile function associated with incubation in culture media.
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1,25 (OH)2 维生素 D3 可减轻与培养基中孵育相关的阻力动脉收缩功能的丧失。
DOI:
10.1016/0006-291x(91)90477-o
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发表时间:
1991
影响因子:
3.1
通讯作者:
Bukoski,RD
中科院分区:
文献类型:
--
作者:
Xue,H;McCarron,DA;Bukoski,RD
Contractile properties of rat mesenteric resistance arteries were studied immediately after isolation or after 48-hr incubation in culture medium [Dulbecco's modified Eagle's/Ham's F-12 (1:1) with insulin, transferrin and antibiotics]. Incubation in culture medium depressed active stress generating capacity, increased sensitivity to norepinephrine and ablated endothelium-dependent relaxation. The decrease in stress generation results from the loss of a releasable pool of intracellular Ca2+; the enhanced sensitivity is associated with decreased neuronal amine pump function. Addition of 300 pg/ml 1,25 (OH)2vitamin D3to the culture medium afforded nearly complete protection against the loss of stress generating capacity and partially preserved endothelial function. It is concluded that 1,25 (OH)2vitamin D3partially prevents phenotypic modulation of the vascular myocyte induced by culture conditions.
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DOI:
10.1161/01.hyp.16.5.523
发表时间:
1990
期刊:
Hypertension (Dallas, Tex. : 1979)
影响因子:
--
作者:
Bukoski,RD;Wang,DB;Wagman,DW
通讯作者:
Wagman,DW
DOI:
10.1016/0006-291x(87)90795-9
发表时间:
1987
影响因子:
3.1
作者:
R. Bukoski;H. Xue;D. McCarron
通讯作者:
D. McCarron
DOI:
10.1016/s0006-291x(88)80439-x
发表时间:
1988-05-16
影响因子:
3.1
作者:
INOUE, T;KAWASHIMA, H
通讯作者:
KAWASHIMA, H
影响因子:
37.8
作者:
Atsuko Yanagisawa;Hideki Ito;Tsuneaki Sugimoto
通讯作者:
Tsuneaki Sugimoto
影响因子:
7.7
作者:
Shinji Yagi;S. Takata;Hiroaki Kiyokawa;M. Yamamoto;Y. Noto;T. Ikeda;N. Hattori
通讯作者:
N. Hattori