Neurobiological underpinnings of insight deficits in schizophrenia

Neurobiological underpinnings of insight deficits in schizophrenia
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精神分裂症洞察力缺陷的神经生物学基础

DOI:
--
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发表时间:
2007
影响因子:
2.8
通讯作者:
A. David
A. David
中科院分区:
医学4区
文献类型:
--
作者:
M. Shad;M. Keshavan;C. Tamminga;C. Munro Cullum;A. David

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对疾病的洞察力受损在各种精神疾病中都很常见,但在精神分裂症患者中最为常见。自知力差的临床相关性和对公共健康的影响反映在它与重要的临床结果指标密切相关,如治疗不坚持、心理社会功能较低、预后较差、非自愿住院和急救服务利用率较高。虽然自知力的神经生物学尚未确定,但来自神经认知和一些结构成像研究的数据为精神分裂症自知力功能的神经生物学基础提供了一些了解。利用已发表的和初步的数据,我们提出了一个假想的洞察力模型,可能有助于启动这一复杂领域的神经生物学研究。
Impaired insight into illness is commonly observed across various psychiatric illnesses, but is most frequent in patients with schizophrenia. The clinical relevance and public health impact of poor insight is reflected by its close association with important clinical outcome measures, such as treatment non-adherence, lower psychosocial functioning, poor prognosis, involuntary hospitalization, and higher utilization of emergency services. Although the neurobiology of insight has not been determined, data from neurocognitive and a few structural imaging studies provide some understanding of the neurobiological underpinnings of insight function in schizophrenia. Using published and preliminary data, we propose a hypothetical model of insight that may help initiate neurobiological investigations in this complex area.
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