Chlamydia trachomatis control requires a vaccine.

Chlamydia trachomatis control requires a vaccine.
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DOI:
10.1016/j.vaccine.2013.01.024
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发表时间:
2013-04-08
期刊:
影响因子:
5.5
通讯作者:
Rappuoli, Rino
Rappuoli, Rino
中科院分区:
医学3区
文献类型:
--
作者:
Brunham, Robert C.;Rappuoli, Rino
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沙眼衣原体是北美和欧洲报告的最常见的传染病,是基于筛查和治疗的协调一致的公共卫生控制工作的重点。出乎意料的是,控制努力伴随着再感染率的上升,部分原因是阻止了群体免疫力的发展。通过检测和治疗计划缩短感染持续时间是免疫停滞假说背后的根本原因,因此疫苗对控制工作至关重要。衣原体疫苗组学的进展表明,沙眼衣原体抗原可用于构成亚单位疫苗,疫苗解决方案似乎在科学上是可以实现的。我们建议,加速沙眼原体疫苗工作需要学术界、公共卫生和私营部门参与者之间的协调伙伴关系,并承诺将沙眼原体疫苗控制作为全球公共卫生优先事项。
As the most common reported communicable disease in North America and Europe, Chlamydia trachomatis is the focus of concerted public health control efforts based on screening and treatment. Unexpectedly control efforts are accompanied by rising reinfection rates attributed in part to arresting the development of herd immunity. Shortening the duration of infection through the testing and treatment program is the root cause behind the arrested immunity hypothesis and because of this a vaccine will be essential to control efforts. Advances in Chlamydia vaccinomics have revealed the C. trachomatis antigens that can be used to constitute a subunit vaccine and a vaccine solution appears to be scientifically achievable. We propose that an accelerated C. trachomatis vaccine effort requires coordinated partnership among academic, public health and private sector players together with a commitment to C. trachomatis vaccine control as a global public health priority.
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