Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease.
Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease.
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DOI：
10.1038/s41598-023-34598-7
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发表时间：
2023-06-27
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然大多数SARS-CoV-2感染者的病情相对较轻，在社区得到管理，但在大流行的早期，人们注意到，具有心血管风险因素的个体更有可能出现严重的急性疾病，需要住院治疗。随着大流行的发展，越来越多的人对SARS-CoV-2感染后许多人的症状持续时间长感到担忧，包括大多数在社区接受紧急治疗的人。长期症状持续的危险因素，包括生物学变量，仍然定义不清。在这里，我们研究了疾病后的代谢谱，使用核磁共振（Nightingale Health Oyj），肠道微生物组谱，使用鸟枪宏基因组测序（Illumina Inc），在2561个社区居住的参与者与SARS-CoV-2。疾病持续时间从无症状（n = 307）到COVID后综合征（n = 180）不等，包括长期非COVID-19疾病的参与者（n = 287）。我们还评估了预先建立的代谢组学生物标志物评分，该评分先前与急性肺炎和严重急性COVID-19疾病的住院治疗相关，其与疾病持续时间的相关性。我们发现致动脉粥样硬化-血脂异常代谢谱，包括脂肪酸和胆固醇等生物标志物，与较长的疾病持续时间相关，无论是在有或没有SARS-CoV-2感染的个体中。无论是否感染SARS-CoV-2，先前存在的代谢组学生物标志物评分值越高，疾病持续时间越长。我们发现疾病持续时间和恢复期肠道微生物组之间没有关联。这凸显了心脏代谢功能障碍在急性感染（COVID-19以及其他疾病）症状后出现长时间症状方面的潜在作用。
Whilst most individuals with SARS-CoV-2 infection have relatively mild disease, managed in the community, it was noted early in the pandemic that individuals with cardiovascular risk factors were more likely to experience severe acute disease, requiring hospitalisation. As the pandemic has progressed, increasing concern has also developed over long symptom duration in many individuals after SARS-CoV-2 infection, including among the majority who are managed acutely in the community. Risk factors for long symptom duration, including biological variables, are still poorly defined. Here, we examine post-illness metabolomic profiles, using nuclear magnetic resonance (Nightingale Health Oyj), and gut-microbiome profiles, using shotgun metagenomic sequencing (Illumina Inc), in 2561 community-dwelling participants with SARS-CoV-2. Illness duration ranged from asymptomatic (n = 307) to Post-COVID Syndrome (n = 180), and included participants with prolonged non-COVID-19 illnesses (n = 287). We also assess a pre-established metabolomic biomarker score, previously associated with hospitalisation for both acute pneumonia and severe acute COVID-19 illness, for its association with illness duration. We found an atherogenic-dyslipidaemic metabolic profile, including biomarkers such as fatty acids and cholesterol, was associated with longer duration of illness, both in individuals with and without SARS-CoV-2 infection. Greater values of a pre-existing metabolomic biomarker score also associated with longer duration of illness, regardless of SARS-CoV-2 infection. We found no association between illness duration and gut microbiome profiles in convalescence. This highlights the potential role of cardiometabolic dysfunction in relation to the experience of long duration symptoms after symptoms of acute infection, both COVID-19 as well as other illnesses.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
DOI：
10.1016/j.lanepe.2021.100252
发表时间：
2022-01
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Allen H;Vusirikala A;Flannagan J;Twohig KA;Zaidi A;Chudasama D;Lamagni T;Groves N;Turner C;Rawlinson C;Lopez-Bernal J;Harris R;Charlett A;Dabrera G;Kall M;COVID-19 Genomics UK (COG-UK Consortium)
通讯作者：
COVID-19 Genomics UK (COG-UK Consortium)
影响因子：
7.7
作者：
Beghini F;McIver LJ;Blanco-Míguez A;Dubois L;Asnicar F;Maharjan S;Mailyan A;Manghi P;Scholz M;Thomas AM;Valles-Colomer M;Weingart G;Zhang Y;Zolfo M;Huttenhower C;Franzosa EA;Segata N
通讯作者：
Segata N
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ
影响因子：
4.6
作者：
Barrios C;Zierer J;Würtz P;Haller T;Metspalu A;Gieger C;Thorand B;Meisinger C;Waldenberger M;Raitakari O;Lehtimäki T;Otero S;Rodríguez E;Pedro-Botet J;Kähönen M;Ala-Korpela M;Kastenmüller G;Spector TD;Pascual J;Menni C
通讯作者：
Menni C